NAGLU

Understanding Entity Pages

This page aggregates everything SciDEX knows about NAGLU: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Alpha-N-Acetylglucosaminidase — lysosomal enzyme deficient in Sanfilippo syndrome type B, involved in glycosaminoglycan degradation and neurodegeneration

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flowchart TD
    N0["NAGLU"]
    N1["ACTB"]
    N1 -->|"activates"| N0
    N2["ATG12"]
    N2 -->|"activates"| N0
    N3["ATG5"]
    N3 -->|"activates"| N0
    N4["ATG7"]
    N4 -->|"activates"| N0
    N5["BECN1"]
    N5 -->|"activates"| N0
    N6["CTSD"]
    N6 -->|"activates"| N0
    N7["CTSL"]
    N7 -->|"activates"| N0
    N8["GFP"]
    N8 -->|"activates"| N0
    N9["PLA2G4A"]
    N0 -->|"activates"| N9
    N10["RBFOX3"]
    N0 -->|"activates"| N10
    N11["Alzheimer's disease"]
    N0 -->|"activates"| N11
    N12["neurodegeneration"]
    N0 -->|"activates"| N12
    N13["autophagy pathway"]
    N0 -->|"participates in"| N13
    N14["RNA"]
    N0 -->|"activates"| N14
    N15["traumatic brain injury"]
    N0 -->|"activates"| N15

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    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
    classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
    classDef process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef biological_process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef concept fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    classDef entity fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef index fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    class N0 protein
    class N1 gene
    class N2 gene
    class N3 gene
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 gene
    class N9 gene
    class N10 gene
    class N11 disease
    class N12 disease
    class N13 pathway
    class N14 gene
    class N15 disease

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