gene 1,010 words KG: RBFOX3
Contents

RNA Binding Fox-3 Homolog (NeuN) (RBFOX3)

🧬 Gene Info
Gene SymbolRBFOX3
Full NameRNA Binding Fox-3 Homolog (NeuN) (RBFOX3)
AliasesRNA Binding Protein Fox-3
Chromosome17q21.31
Protein TypeGene
FunctionNuclear Localization: Predominantly localizes to the nucleus of most post-mitotic neurons.
Primary Expressionnearly all neurons in the central and peripheral nervous system
Subcellular Localization, providing additional layers of control over RBFOX3 activity
UniProt IDQ8WWI5
NCBI Gene ID22998
Ensembl IDENSG00000161981
GeneCardsRBFOX3
Human Protein AtlasRBFOX3
Associated DiseasesRett Syndrome, Intellectual Disability, Epilepsy, Autism Spectrum Disorder
Known Drugs/Compoundsrapamycin
InteractionsACTB, AIF1, AMPK, ARC, ATF6, ATG
KG Connections57 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (6)

TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
TREM2-mediated microglial tau clearance enhancement
Score: 0.59
TREM2-Dependent Microglial Senescence Transition
Score: 0.95
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
APOE-TREM2 Interaction Modulation
Score: 0.74

Related Analyses (9)

How do dilncRNAs specifically drive molecular crowding and p
neurodegeneration · completed
What determines the specificity of DDR protein recruitment t
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD AD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived

Related Experiments (30)

FLS Stimulation and Transcriptomic Analysis
exploratory · proposed · Score: 0.95
Single-cell RNA-seq analysis of mouse testes with gonadal de
exploratory · proposed · Score: 0.95
Myricanol treatment in HFD-induced hyperlipidemic C57BL/6J m
validation · proposed · Score: 0.95
Sevoflurane-induced neurotoxicity (SIN) rat model
validation · proposed · Score: 0.95
LINC00599 expression analysis in hypoxic PH models
exploratory · proposed · Score: 0.90

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (12 edges)

AIF1 activates RBFOX3
ARC activates RBFOX3
CAMKK2 activates RBFOX3
COX4I1 activates RBFOX3
GFAP activates RBFOX3
IBA1 activates RBFOX3
LAMP2 activates RBFOX3
MAP1LC3B activates RBFOX3
NEFM activates RBFOX3
NFM activates RBFOX3

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