gene 2,449 words KG: PRDX6
Contents

PRDX6 Gene

🧬 Gene Info
Gene SymbolPRDX6
Full NamePeroxiredoxin 6
Chromosome1q25.1
Functionis a unique member of the peroxiredoxin family with distinctive dual enzyme activities that set it apart from other peroxiredoxins.
Primary ExpressionBrain, Liver, Lung, Heart, Kidney
Molecular Weight25 kDa
Amino Acids224 aa
Exons9
PathwaysMitophagy
UniProt IDP30041
NCBI Gene ID9588
Ensembl IDENSG00000119004
OMIM603351
GeneCardsPRDX6
Human Protein AtlasPRDX6
Associated DiseasesAging, Als, Cancer, Cardiovascular, Ms, neuroinflammation
InteractionsALZHEIMER, ALZHEIMER'S DISEASE, AND, APOE, ASTROCYTE, ASTROCYTES
KG Connections208 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (10)

Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66
KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.65
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Arginine Methylation Enhancement Therapy
Score: 0.65

Related Analyses (5)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Microbiome-Gut-Brain Axis in Alzheimer's Disease — mechanism
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (15)

Astrocytes
cell · KG edge: activates
Astrocytes
entity · KG edge: activates
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: interacts_with
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
ACTB Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

P38 activates PRDX6
IL1B activates PRDX6
PRDX1 activates PRDX6
TRAF6 activates PRDX6
CHUK activates PRDX6
PRDX6 activates MAPK14
PRDX6 activates BECN1
PRDX6 activates TNF
PRDX6 activates ECSIT
PRDX6 activates MAP3K7

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.