protein

COX5A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about COX5A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

0Hypotheses

0Analyses

14Outgoing

0Incoming

0Experiments

0Debates

Summary

Page for COX5A Protein

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🔬 Protein Info

Gene Symbol	COX5A
Full Name	Cytochrome C Oxidase Subunit 5A
Chromosome	15q15.3
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	tissues with high oxidative metabolism, including:
Molecular Weight	16 kDa
Amino Acids	150 aa
Pathways	NAD+ metabolism
UniProt ID	[P20674](https://www.uniprot.org/uniprot/P20674)
Ensembl ID	ENSG00000178741
GeneCards	COX5A
Human Protein Atlas	COX5A
Neurons	high energy demand for synaptic function
Cardiac muscle	continuous contraction
Skeletal muscle	exercise-induced mitochondrial biogenesis
Associated Diseases	neurodegeneration
Interactions	NRF1, SIRT3, TFAM
KG Connections	14 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

COX5A Gene

gene · 502 words

→

COX5A Protein

protein · 555 words

→

Pathway Diagram

graph TD
    COX5A["COX5A"]
    Carcinoma{"Carcinoma"}
    COX5A -->|"inhibits"| Carcinoma
    Ms{"Ms"}
    COX5A -->|"inhibits"| Ms
    Tumor{"Tumor"}
    COX5A -->|"contributes to"| Tumor
    PRDX6["PRDX6"]
    COX5A -->|"contributes to"| PRDX6
    PRDX3["PRDX3"]
    COX5A -->|"contributes to"| PRDX3
    SOD2["SOD2"]
    COX5A -->|"contributes to"| SOD2
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    COX5A -->|"contributes to"| OXIDATIVE_STRESS
    Oxidative_Stress(["Oxidative Stress"])
    COX5A -->|"contributes to"| Oxidative_Stress
    neurodegeneration["neurodegeneration"]
    COX5A -->|"implicated in"| neurodegeneration
    style COX5A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (14)

Target	Relation	Type	Str
Carcinoma	inhibits	disease	0.65
Tumor	contributes_to	disease	0.65
Ms	inhibits	disease	0.65
Oxidative Stress	contributes_to	pathway	0.60
OXIDATIVE STRESS	contributes_to	gene	0.60
PRDX6	contributes_to	gene	0.60
PRDX3	contributes_to	gene	0.60
SOD2	contributes_to	gene	0.60
NRF1	inhibits	gene	0.55
NAD+ metabolism	participates_in	pathway	0.55
TFAM	inhibits	gene	0.55
SIRT3	inhibits	gene	0.55
excitatory neurons	expressed_in	cell_type	0.55
neurons	expressed_in	cell_type	0.55

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning COX5A in their description or question text

No additional research found