gene 2,014 words KG: PKC
Contents

PRKCA Gene

🧬 Gene Info
Gene SymbolPKC
Full NameProtein Kinase C Alpha
Chromosome17q24.2
Protein FamilyPKC (Protein Kinase C) family
Amino Acids672 aa
Exons17
PathwaysAkt, Apoptosis, Autophagy, Complement, Differentiation
UniProt ID[P17252](https://www.uniprot.org/uniprot/P17252)
Ensembl IDENSG00000154229
OMIM176960
GeneCardsPKC
Human Protein AtlasPKC
Associated DiseasesAls, Alzheimer, Ataxia, Diabetes, Ms
Known Drugs/Compoundsmetformin
InteractionsAGING, AKT, ALOX5, AMPK, Amyloid, AMYLOID
KG Connections526 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (25)

Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
APOE-Dependent Autophagy Restoration
Score: 0.88
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.72
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
Purinergic Signaling Polarization Control
Score: 0.71
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Extracellular Matrix Stiffness Modulation
Score: 0.69
Hypocretin-Neurogenesis Coupling Therapy
Score: 0.69
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68
Flotillin-1 Stabilization Compounds
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
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Related Analyses (10)

Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

See Also (9)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: inhibits
Astrocytes
entity · KG edge: interacts_with
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: interacts_with

Knowledge Graph (12 edges)

PKC activates NRF2
PKC associated_with PRKCG
EEF2 activates PKC
PKC activates TNF
PKC activates FYN
PKC activates KEAP1
PKC activates CUL3
PKC activates BACH1
PKC associated_with MTOR
PKC inhibits ANG

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