gene 3,060 words KG: PARK7
Contents

PARK7 — Parkinsonism Associated Deglycase (DJ-1)

🧬 Gene Info
Gene SymbolPARK7
Full NameParkinsonism Associated Deglycase (DJ-1)
AliasesPage for PARK7 Gene
Chromosome1p36.23
Protein TypeProtein
FunctionDJ-1 has multiple cellular functions
Primary ExpressionHigh in brain (substantia nigra), testis, kidney
Subcellular LocalizationCytoplasm, nucleus, mitochondria
Molecular Weight20 kDa
Amino Acids189 aa
PathwaysAlpha-Synuclein, Autophagy, Epigenetic, Er Stress, Inflammasome
UniProt IDQ99497
GeneCardsPARK7
Human Protein AtlasPARK7
Associated DiseasesAD, Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
InteractionsACETYL-COA, AD, AGING, AKT, Alpha-Synuclein, ALS
KG Connections610 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (19)

TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Circadian Clock-Autophagy Synchronization
Score: 0.76

Related Analyses (7)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived

Related Experiments (1)

Gap Junction Dysfunction Validation in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (8)

ABCA7 (Redirect)
redirect · KG edge: associated_with
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: interacts_with
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with

Knowledge Graph (12 edges)

PARK7 associated_with neurodegeneration
PARK7 regulates SOD1
SOD1 regulates PARK7
PARK7 associated_with SOD1
PARK7 associated_with TAU
LRRK2 associated_with PARK7
PARK7 co_discussed SOD1
PARK7 co_discussed TAU
LRRK2 co_discussed PARK7
PARK7 co_discussed PINK1

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