Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PGC1ALPHA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | PGC1ALPHA |
| Key Genes/Proteins | ALPHA-SYNUCLEIN, AND, App, DJ-1, DJ1, HNRNPA1 |
| Related Diseases | Alzheimer, Amyotrophic Lateral Sclerosis, Huntington, HUNTINGTON'S DISEASE |
| Related Pathways | Alpha-Synuclein, Amyloid, Er Stress |
Knowledge base pages for this entity
graph TD
PGC1ALPHA["PGC1ALPHA"]
PGC1ALPHA -->|"regulates"| Parkinson["Parkinson"]
PGC1ALPHA -->|"regulates"| NURR1["NURR1"]
PGC1ALPHA -->|"regulates"| PARK7["PARK7"]
PGC1ALPHA -->|"regulates"| PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
PGC1ALPHA -->|"regulates"| ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
PGC1ALPHA -->|"regulates"| Synaptic_Plasticity["Synaptic Plasticity"]
PGC1ALPHA -->|"regulates"| Er_Stress["Er Stress"]
PGC1ALPHA -->|"regulates"| Alpha_Synuclein["Alpha-Synuclein"]
LMX1B["LMX1B"] -->|"regulates"| PGC1ALPHA
PINK1["PINK1"] -->|"regulates"| PGC1ALPHA
PARKINSON["PARKINSON"] -->|"regulates"| PGC1ALPHA
SNCA["SNCA"] -->|"regulates"| PGC1ALPHA
SFPQ["SFPQ"] -->|"regulates"| PGC1ALPHA
DJ_1["DJ-1"] -->|"regulates"| PGC1ALPHA
AND["AND"] -->|"regulates"| PGC1ALPHA
NFM["NFM"] -->|"regulates"| PGC1ALPHA| Target | Relation | Type | Str |
|---|---|---|---|
| HUNTINGTON'S DISEASE | downregulates | disease | 0.80 |
| Parkinson | regulates | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | regulates | disease | 0.65 |
| Neurodegeneration | regulates | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Huntington | regulates | disease | 0.65 |
| NFM | regulates | gene | 0.60 |
| DJ1 | regulates | gene | 0.60 |
| PARKIN | regulates | gene | 0.60 |
| PARKINSON'S DISEASE | regulates | gene | 0.60 |
| ALPHA-SYNUCLEIN | regulates | gene | 0.60 |
| NURR1 | regulates | gene | 0.60 |
| Synaptic Plasticity | regulates | pathway | 0.60 |
| Er Stress | regulates | pathway | 0.60 |
| Alpha-Synuclein | regulates | pathway | 0.60 |
| App | regulates | protein | 0.60 |
| PARK7 | regulates | gene | 0.60 |
| Oxidative Stress | regulates | pathway | 0.60 |
| Amyloid | regulates | pathway | 0.60 |
| LMX1B | regulates | gene | 0.60 |
| HNRNPA1 | regulates | gene | 0.60 |
| SNCA | regulates | gene | 0.60 |
| PINK1 | regulates | gene | 0.60 |
| DJ-1 | regulates | gene | 0.60 |
| PARKINSON | regulates | gene | 0.60 |
| Dopaminergic | regulates | cell_type | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SIRT1 Activation Couples Mitochondrial Biogenesis to Ferropt | 0.824 | neurodegeneration | View |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Irisin effects on osteogenic differentiation in mesenchymal stem cells | exploratory | bone fracture | 0.900 | 0.00 | mouse bone mesenchymal stem ce | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PGC1ALPHA in their description or question text
No additional research found