protein

SFPQ

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SFPQ: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

126Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

SFPQ is a protein involved in neurodegeneration research. Key relationships include: interacts with, implicated in. Associated with Als, Carcinoma, Hepatitis. Connected to 10 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	SFPQ
Full Name	Splicing Factor Proline and Glutamine Rich
Chromosome	1p35.3
Protein Type	RNA-binding protein, Splicing factor
Function	encodes a nuclear RNA-binding protein that functions as a critical regulator of alternative splicing, transcriptional regulation, and RNA processing.
Molecular Weight	76 kDa
Amino Acids	664 aa
Pathways	Alpha-Synuclein, Er Stress, Synaptic Plasticity
UniProt ID	[P23246](https://www.uniprot.org/uniprot/P23246)
Ensembl ID	ENSG00000116560
OMIM	605199
GeneCards	SFPQ
Human Protein Atlas	SFPQ
N-terminal domain	Contains multiple proline-rich motifs that mediate protein-protein interactions
RNA recognition motif (RRM) domains	Two RRM domains that bind RNA and single-stranded DNA
Associated Diseases	Als, Alzheimer, Parkinson
Interactions	ALZHEIMER, APOE, APP, CALB1, CCNF, CCT4
KG Connections	126 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SFPQ Gene

gene · 1312 words

→

SFPQ Protein

protein · 913 words

→

Pathway Diagram

graph TD
    SFPQ["SFPQ"]
    Als{"Als"}
    SFPQ -->|"interacts with"| Als
    Hepatitis{"Hepatitis"}
    SFPQ -->|"interacts with"| Hepatitis
    Ms{"Ms"}
    SFPQ -->|"interacts with"| Ms
    Carcinoma{"Carcinoma"}
    SFPQ -->|"interacts with"| Carcinoma
    PTBP1["PTBP1"]
    SFPQ -->|"interacts with"| PTBP1
    TARDBP["TARDBP"]
    SFPQ -->|"interacts with"| TARDBP
    HNRNPK["HNRNPK"]
    SFPQ -->|"interacts with"| HNRNPK
    neurodegeneration["neurodegeneration"]
    SFPQ -->|"implicated in"| neurodegeneration
    NPM1["NPM1"]
    NPM1 -->|"interacts with"| SFPQ
    PARP1["PARP1"]
    PARP1 -->|"interacts with"| SFPQ
    style SFPQ fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (67)

Target	Relation	Type	Str
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Hepatitis	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Carcinoma	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
ALS	associated_with	disease	0.65
Parkinson	regulates	disease	0.65
AND	regulates	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
ALPHA-SYNUCLEIN	regulates	gene	0.60
Synaptic Plasticity	regulates	pathway	0.60
Er Stress	regulates	pathway	0.60
Alpha-Synuclein	regulates	pathway	0.60
DJ-1	interacts_with	gene	0.60
Actin	associated_with	protein	0.60
Alzheimer's disease	interacts_with	disease	0.60
VCP	interacts_with	gene	0.60
Parkinson	associated_with	disease	0.60
PTBP1	interacts_with	gene	0.60
TARDBP	interacts_with	gene	0.60
HNRNPK	interacts_with	gene	0.60
NFM	regulates	gene	0.60
HNRNPA1	regulates	gene	0.60
PGC1ALPHA	regulates	gene	0.60
NURR1	interacts_with	gene	0.60
PARK7	interacts_with	gene	0.60
TMEM59	associated_with	gene	0.60
SYNCRIP	associated_with	gene	0.60
ULK2	associated_with	gene	0.60
IDS	associated_with	gene	0.60
SSBP1	associated_with	gene	0.60
SRSF1	associated_with	gene	0.60
neurodegeneration	activates	disease	0.60
COPA	associated_with	gene	0.60
Igf	associated_with	protein	0.60
SMARCB1	associated_with	gene	0.60
SYNE2	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
CCT4	associated_with	gene	0.60
CALB1	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
IGF2R	associated_with	gene	0.60
STXBP3	associated_with	gene	0.60
RNF14	associated_with	gene	0.60
APP	associated_with	gene	0.60
APOE	associated_with	gene	0.60
PRDX3	associated_with	gene	0.60
CCNH	associated_with	gene	0.60
Rb	expressed_in	protein	0.60

Incoming (59)

Source	Relation	Type	Str
CELF2	interacts_with	protein	0.92
RNF14	associated_with	gene	0.60
STXBP3	associated_with	gene	0.60
IGF2R	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
CCT4	associated_with	gene	0.60
RNA	interacts_with	gene	0.60
MAP1B	associated_with	gene	0.60
MACF1	associated_with	gene	0.60
HSP90AA1	associated_with	gene	0.60
FUS	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
COPA	interacts_with	gene	0.60
IDS	associated_with	gene	0.60
SYNCRIP	associated_with	gene	0.60
SSBP1	associated_with	gene	0.60
PRDX3	associated_with	gene	0.60
APP	associated_with	gene	0.60
APOE	associated_with	gene	0.60
SYNE2	associated_with	gene	0.60
SMARCB1	associated_with	gene	0.60
ULK2	associated_with	gene	0.60
TMEM59	associated_with	gene	0.60
RNA	activates	gene	0.60
FTLD	activates	gene	0.60
APP	interacts_with	gene	0.60
IDS	interacts_with	gene	0.60
IGF2R	interacts_with	gene	0.60
FUS	activates	gene	0.60
MUC1	activates	gene	0.60
MYC	activates	gene	0.60
NONO	activates	gene	0.60
CCNF	interacts_with	gene	0.60
AND	associated_with	gene	0.60
PARKINSON	regulates	gene	0.60
MAPT	phosphorylates	gene	0.60
COPA	associated_with	gene	0.60
NPM1	interacts_with	gene	0.60
PARP1	interacts_with	gene	0.60
LMX1B	regulates	gene	0.60
PINK1	regulates	gene	0.60
SNCA	regulates	gene	0.60
FUS	phosphorylates	gene	0.60
PARK7	interacts_with	gene	0.50
PINK1	co_expressed_with	gene	0.50
CALB1	interacts_with	gene	0.50
RNF14	interacts_with	gene	0.50
CCT4	interacts_with	gene	0.50
ULK2	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SFPQ in their description or question text

No additional research found