protein 1,073 words KG: DJ1PARK7
Contents

PARK7 — Parkinsonism Associated Deglycase (DJ-1)

🔬 Protein Info
Gene SymbolDJ1PARK7
AliasesDJ1PARK7
Chromosome1p36.22
Thiolase activityDJ-9 possesses deglycase activity that repairs methylglyoxal- and glyoxal-modified proteins[@miyamura2020]
Cysteine residue (Cys106)Critical for oxidative stress sensing; forms sulfinic acid under oxidative conditions[@wilson2011]
Homodimer formationFunctional unit required for neuroprotective activity[@wu2018]
Dimeric structureFunctional unit requires dimerization
Cysteine residuesCys106 is critical for oxidative stress sensing
pH sensitivityActivity modulated by protonation state
Metal bindingCan bind zinc and copper
PDA modificationPyruvate dehydrogenase activity
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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