concept

NUCLEUS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NUCLEUS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

303Connections

4Hypotheses

1Analyses

11Outgoing

50Incoming

0Experiments

1Debates

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💡 Concept Info

Name	NUCLEUS
Key Genes/Proteins	ABCD3, AIM2, ALZHEIMER, AMBRA1, ANXA1, ANXIETY
Related Diseases	acetylcholine, aging, Alzheimer Disease, Alzheimer'S Disease

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Nucleus Vestibularis Superior Expanded (SuVe)

cell · 2984 words

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Pathway Diagram

graph TD
    NUCLEUS["NUCLEUS"]
    NUCLEUS -->|"component_of"| Genome_Packaging["Genome Packaging"]
    NUCLEUS -->|"activates"| PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    NUCLEUS -->|"activates"| ROS["ROS"]
    NUCLEUS -->|"activates"| SQSTM1["SQSTM1"]
    NUCLEUS -->|"activates"| STAT3["STAT3"]
    NUCLEUS -->|"regulates"| PREFRONTAL_CORTEX["PREFRONTAL CORTEX"]
    NUCLEUS -->|"regulates"| THALAMUS["THALAMUS"]
    NEURON["NEURON"] -->|"regulates"| NUCLEUS
    HYPOTHALAMUS["HYPOTHALAMUS"] -->|"regulates"| NUCLEUS
    CORTEX["CORTEX"] -->|"expressed in"| NUCLEUS
    Inter_chromosomal_Hubs["Inter-chromosomal Hubs"] -->|"component_of"| NUCLEUS
    CASP2["CASP2"] -->|"expressed in"| NUCLEUS
    ENDOPLASMIC_RETICULUM["ENDOPLASMIC RETICULUM"] -->|"activates"| NUCLEUS

Outgoing (11)

Target	Relation	Type	Str
Genome Packaging	component_of	process	0.85
ENDOPLASMIC RETICULUM	activates	concept	0.50
AMYGDALA	associated_with	concept	0.50
CEREBRAL CORTEX	associated_with	concept	0.50
TEMPORAL LOBE	associated_with	concept	0.50
SRPK1	inhibits	concept	0.50
SRPK1	activates	concept	0.50
INTERNEURONS	interacts_with	concept	0.50
HEPATOCYTES	associated_with	concept	0.50
HEPATOCYTES	interacts_with	concept	0.50
INTERNEURONS	associated_with	concept	0.50

Incoming (292)

Source	Relation	Type	Str
cell-types-nucleus-basalis-meynert	describes	wiki	1.00
CHMP2BIn5	associated_with	protein	0.95
3D genome organization	involved_in	process	0.95
NPM1	transports	protein	0.90
Inter-chromosomal Hubs	component_of	process	0.90
APOE	translocates_to	gene	0.80
CASP2	expressed_in	protein	0.72
ANXA1	interacts_with	protein	0.70
DNAJB6a	regulates	protein	0.70
GABARAP	activates	protein	0.50
DNA DAMAGE	activates	concept	0.50
TREM2	associated_with	gene	0.50
MAP1LC3A	activates	gene	0.50
TFE3	activates	gene	0.50
BCL2L13	activates	gene	0.50
PEX3	activates	gene	0.50
BNIP3L	activates	protein	0.50
OPTINEURIN	activates	protein	0.50
OPTN	activates	gene	0.50
BCL2L11	activates	gene	0.50
PTEN	activates	gene	0.50
PARKINSON	activates	gene	0.50
EIF2S1	activates	concept	0.50
disease	activates	disease	0.50
PGC-1Α	activates	protein	0.50
PPAR	activates	protein	0.50
GLUT4	activates	concept	0.50
GENE EXPRESSION	activates	concept	0.50
ANXA1	associated_with	protein	0.50
microglia	associated_with	cell_type	0.50
ISCHEMIC	associated_with	concept	0.50
Protein Aggregation	activates	process	0.50
PARKINSON'S	activates	concept	0.50
α-SYNUCLEIN	activates	concept	0.50
Tdp-43	regulates	pathway	0.50
disease	interacts_with	disease	0.50
Alzheimer'S Disease	activates	disease	0.50
ALZHEIMER'S	activates	concept	0.50
aging	associated_with	phenotype	0.50
Astrocytes	associated_with	cell_type	0.50
Astrocyte	associated_with	cell_type	0.50
late	associated_with	disease	0.50
THALAMUS	regulates	concept	0.50
Neuron	associated_with	cell_type	0.50
HCRT	associated_with	concept	0.50
AIM2	activates	gene	0.50
HUNTINGTIN	expressed_in	protein	0.50
Pi3K	activates	pathway	0.50
Astrocytes	regulates	cell_type	0.50
Protein Aggregation	interacts_with	process	0.50

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Thalamic Reticular Nucleus (TRN) GluN2B Hyperexcitability Di	0.633	neuroscience	GluN2B-Mediated Thalamocortical Control
MT1 Receptor Activation at Low Doses Synchronizes Suprachias	0.405	-	What is the minimum effective dose of tr
Thalamic anterior nucleus hyperconnectivity drives early-sta	0.380	alzheimers	Human connectome alterations and network
Adaptive Deep Brain Stimulation Targeting the Pedunculoponti	0.000	-	GBA-Synuclein Loop: Therapeutic Strategi

Mentioning Analyses (1)

Scientific analyses that reference this entity

Does DNAJB6 directly inhibit cross-seeding between tau, α-synuclein, and TDP-43

neurodegeneration | 2026-04-12 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate revealed that DNAJB6 evidence is limited to polyglutamine aggregation

closed · Rounds: 4 · Score: 0.79 · 2026-04-16

Related Research

Hypotheses and analyses mentioning NUCLEUS in their description or question text

No additional research found