gene

NURR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NURR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

207Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

NURR1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with Als, Inflammation, Ms. Connected to 40 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NURR1
Full Name	Nuclear Receptor Related 1
Protein Type	Protein
Target Class	Protein
Function	NURR1 is an orphan nuclear receptor with ligand-independent activity:
Mechanism of Action	Prioritized from 1 SciDEX hypotheses, including: Programmable Neuronal Circuit Repair via Epigenetic CRISPR
Druggability	Undruggable (0.23)
Amino Acids	598 aa
Exons	8
Pathways	Alpha-Synuclein, Autophagy, Er Stress, Synaptic Plasticity
UniProt ID	Search UniProt
Ensembl ID	ENSG00000153234
GeneCards	NURR1
Human Protein Atlas	NURR1
Associated Diseases	neurodegeneration, Parkinson, Parkinson's disease
Known Drugs/Compounds	levodopa
Interactions	AGING, ALPHA-SYNUCLEIN, AMPK, AND, ascl1, ASCL1
SciDEX Target	View Target Profile
KG Connections	207 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: NURR1 — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NURR1["NURR1"]
    Synucleinopathy{"Synucleinopathy"}
    NURR1 -->|"activates"| Synucleinopathy
    Inflammation{"Inflammation"}
    NURR1 -->|"activates"| Inflammation
    Als{"Als"}
    NURR1 -->|"activates"| Als
    Neuroinflammation{"Neuroinflammation"}
    NURR1 -->|"activates"| Neuroinflammation
    Parkinson{"Parkinson"}
    NURR1 -->|"activates"| Parkinson
    NURR1 -->|"regulates"| Parkinson
    Ms{"Ms"}
    NURR1 -->|"expressed in"| Ms
    GFAP["GFAP"]
    NURR1 -->|"activates"| GFAP
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    NURR1 -->|"activates"| NEUROINFLAMMATION
    LAMP1["LAMP1"]
    NURR1 -->|"activates"| LAMP1
    LAMP2["LAMP2"]
    NURR1 -->|"activates"| LAMP2
    AUTOPHAGY["AUTOPHAGY"]
    NURR1 -->|"regulates"| AUTOPHAGY
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"activates"| NURR1
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"activates"| NURR1
    PARKINSON_S_DISEASE -->|"regulates"| NURR1
    LC3B["LC3B"]
    LC3B -->|"activates"| NURR1
    style NURR1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (128)

Target	Relation	Type	Str
DOPAMINERGIC DIFFERENTIATION	promotes	biological_process	0.85
Parkinson	activates	disease	0.85
Inflammation	activates	disease	0.85
Neuroinflammation	activates	disease	0.85
NEUROINFLAMMATION	activates	gene	0.80
ALPHA-SYNUCLEIN	activates	gene	0.70
ALS	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Parkinson	inhibits	disease	0.65
Ms	expressed_in	disease	0.65
Parkinson	regulates	disease	0.65
Aging	activates	disease	0.65
Als	activates	disease	0.65
Synucleinopathy	activates	disease	0.65
Parkinson	associated_with	disease	0.60
Tubulin	expressed_in	protein	0.60
FGFR1	activates	gene	0.60
AGING	activates	gene	0.60
Neurogenesis	activates	pathway	0.60
Dopaminergic	expressed_in	cell_type	0.60
Fibroblast	activates	cell_type	0.60
Neuron	expressed_in	cell_type	0.60
SNCA	regulates	gene	0.60
LRRK2	inhibits	gene	0.60
PRKN	activates	gene	0.60
MICROGLIA	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
MICROGLIA ACTIVATION	activates	gene	0.60
Oxidative Stress	associated_with	pathway	0.60
PARKIN	inhibits	gene	0.60
PARKINSON	regulates	gene	0.60
Er Stress	regulates	pathway	0.60
Synaptic Plasticity	regulates	pathway	0.60
Dopaminergic	interacts_with	cell_type	0.60
GFAP	activates	gene	0.60
VMAT2	activates	gene	0.60
MTOR	activates	gene	0.60
Alpha-Synuclein	regulates	pathway	0.60
ALPHA-SYNUCLEIN	regulates	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
LMX1A	activates	gene	0.60
BDNF	activates	gene	0.60
NGF	activates	gene	0.60
UBIQUITIN	inhibits	gene	0.60
NEURON	activates	gene	0.60
Autophagy	activates	pathway	0.60
Mtor	activates	pathway	0.60
Mapk	activates	pathway	0.60
Fgf	activates	protein	0.60
App	regulates	protein	0.60

Incoming (79)

Source	Relation	Type	Str
h-9d22b570	targets_gene	hypothesis	0.90
SDA-2026-04-02-gap-crispr-neurodegeneration-20260402	targets	analysis	0.80
PARKINSON	activates	gene	0.70
PARKINSON'S DISEASE	activates	gene	0.70
PINK1	regulates	gene	0.60
NFM	regulates	gene	0.60
LMX1B	associated_with	gene	0.60
NGF	activates	gene	0.60
UBIQUITIN	inhibits	gene	0.60
ASCL1	activates	gene	0.60
GDNF	activates	gene	0.60
BDNF	activates	gene	0.60
LMX1A	activates	gene	0.60
TUBULIN	expressed_in	gene	0.60
AND	activates	gene	0.60
HNRNPA1	regulates	gene	0.60
PARK7	interacts_with	gene	0.60
GSK3B	regulates	gene	0.60
LRRK2	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
AMPK	activates	gene	0.60
GENES	activates	gene	0.60
PARKINSON	inhibits	gene	0.60
AND	inhibits	gene	0.60
GENES	inhibits	gene	0.60
NLRP3	associated_with	gene	0.60
NLRP3	co_expressed_with	gene	0.60
ATP13A2	regulates	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
SNCA	regulates	gene	0.60
SFPQ	interacts_with	gene	0.60
PGC1ALPHA	regulates	gene	0.60
LRRK2	inhibits	gene	0.60
PRKN	activates	gene	0.60
PARKIN	inhibits	gene	0.60
P53	activates	gene	0.60
WNT	activates	gene	0.60
NEUROTOXICITY	associated_with	gene	0.60
NEURODEGENERATION	activates	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
PARKIN	activates	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
LC3B	activates	gene	0.60
PARKINSON	regulates	gene	0.60
AND	associated_with	gene	0.60
FGFR1	activates	gene	0.60
CREB	activates	gene	0.60
RNA	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

CRISPR-based therapeutic approaches for neurodegenerative diseases

neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.803

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Evaluate the potential of CRISPR/Cas9 and related gene editing technologies for

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning NURR1 in their description or question text

No additional research found