gene

LMX1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LMX1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

46Connections

0Hypotheses

0Analyses

31Outgoing

15Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	LMX1A
Full Name	LIM Homeobox Transcription Factor 1 Alpha
Chromosome	1q22
Protein Type	Transcription Factor
Function	It regulates gene expression through binding to specific DNA sequences and recruiting transcriptional co-activators or co-repressors.
Primary Expression	substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) dopaminergic neurons
Pathways	WNT signaling, WNT
UniProt ID	Q8WWI6
NCBI Gene ID	26118
Ensembl ID	ENSG00000187123
GeneCards	LMX1A
Human Protein Atlas	LMX1A
Tyrosine hydroxylase (TH)	rate-limiting enzyme in dopamine synthesis
Dopamine transporter (DAT/SLC6A3)	regulates dopamine reuptake
VMAT2 (SLC18A2)	vesicular dopamine transporter
Associated Diseases	neurodegeneration
Interactions	AND, ascl1, ASCL1, Bdnf, BDNF, DAT
KG Connections	46 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: LMX1A — AlphaFold Q8WWI6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

LMX1A Gene

gene · 843 words

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Pathway Diagram

graph TD
    LMX1A["LMX1A"]
    Als["Als"]
    LMX1A -->|"activates"| Als
    Parkinson["Parkinson"]
    LMX1A -->|"inhibits"| Parkinson
    ALS["ALS"]
    LMX1A -->|"activates"| ALS
    NURR1["NURR1"]
    LMX1A -->|"activates"| NURR1
    PRKN["PRKN"]
    LMX1A -->|"activates"| PRKN
    PARKIN["PARKIN"]
    LMX1A -->|"inhibits"| PARKIN
    PARKINSON["PARKINSON"]
    LMX1A -->|"inhibits"| PARKINSON
    Dopaminergic["Dopaminergic"]
    LMX1A -->|"inhibits"| Dopaminergic
    Fibroblast["Fibroblast"]
    LMX1A -->|"activates"| Fibroblast
    Neuron["Neuron"]
    LMX1A -->|"activates"| Neuron
    GENES["GENES"]
    LMX1A -->|"inhibits"| GENES
    ASCL1["ASCL1"]
    LMX1A -->|"activates"| ASCL1
    BDNF["BDNF"]
    LMX1A -->|"activates"| BDNF
    NGF["NGF"]
    LMX1A -->|"activates"| NGF
    UBIQUITIN["UBIQUITIN"]
    LMX1A -->|"inhibits"| UBIQUITIN
    AND["AND"]
    LMX1A -->|"activates"| AND
    GDNF["GDNF"]
    LMX1A -->|"activates"| GDNF
    P53["P53"]
    LMX1A -->|"activates"| P53
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    LMX1A -->|"inhibits"| PARKINSON_S_DISEASE
    NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"]
    LMX1A -->|"inhibits"| NEURODEGENERATIVE_DISORDERS
    NGF["NGF"]
    NGF -->|"activates"| LMX1A
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"inhibits"| LMX1A
    ASCL1["ASCL1"]
    ASCL1 -->|"activates"| LMX1A
    GDNF["GDNF"]
    GDNF -->|"activates"| LMX1A
    BDNF["BDNF"]
    BDNF -->|"activates"| LMX1A
    P53["P53"]
    P53 -->|"activates"| LMX1A
    Substantia_Nigra["Substantia Nigra"]
    LMX1A -->|"expressed in"| Substantia_Nigra
    Fibroblast["Fibroblast"]
    LMX1A -->|"expressed in"| Fibroblast
    Neuron["Neuron"]
    LMX1A -->|"expressed in"| Neuron
    neurodegeneration["neurodegeneration"]
    LMX1A -->|"implicated in"| neurodegeneration

Outgoing (31)

Target	Relation	Type	Str
ALS	activates	disease	0.65
Als	activates	disease	0.65
Parkinson	inhibits	disease	0.65
Fibroblast	activates	cell_type	0.60
Neuron	activates	cell_type	0.60
ASCL1	activates	gene	0.60
BDNF	activates	gene	0.60
NGF	activates	gene	0.60
UBIQUITIN	inhibits	gene	0.60
PARKINSON	inhibits	gene	0.60
GDNF	activates	gene	0.60
Dopaminergic	inhibits	cell_type	0.60
Gdnf	activates	protein	0.60
Ngf	activates	protein	0.60
Bdnf	activates	protein	0.60
NURR1	activates	gene	0.60
PRKN	activates	gene	0.60
PARKIN	inhibits	gene	0.60
AND	activates	gene	0.60
P53	activates	gene	0.60
PARKINSON'S DISEASE	inhibits	gene	0.60
NEURODEGENERATIVE DISORDERS	inhibits	gene	0.60
GENES	inhibits	gene	0.60
Substantia Nigra	expressed_in	brain_region	0.55
Fibroblast	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55
neurons	expressed_in	cell_type	0.55
PITX3	activates	gene	0.55
TH	activates	gene	0.55
NEURONS	activates	concept	0.50
FIBROBLASTS	activates	concept	0.50

Incoming (15)

Source	Relation	Type	Str
NURR1	activates	gene	0.60
PARKIN	inhibits	gene	0.60
P53	activates	gene	0.60
NGF	activates	gene	0.60
UBIQUITIN	inhibits	gene	0.60
ASCL1	activates	gene	0.60
GDNF	activates	gene	0.60
BDNF	activates	gene	0.60
PARKINSON	inhibits	gene	0.60
EN1	activates	gene	0.55
EN2	activates	gene	0.55
FOXA2	activates	gene	0.55
DAT	activates	gene	0.55
PRKN	activates	gene	0.50
ascl1	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LMX1A in their description or question text

No additional research found