NURR1

NURR1 Protein

Score: 0.307 Price: $0.31 Undruggable Druggability Status: active Wiki: NURR1 Gene

HYPOTHESES

PAPERS

KG EDGES

DEBATES

3D Protein Structure

🧬 NURR1 — PDB 1OVL Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Druggability & Clinical Context

Druggability

Undruggable

Score: 0.23

Clinical Stage

Preclinical

Target Class

Protein

Safety

0.50

Druggability Analysis

Drug Development0.00

Structural Tractability0.30

Target Class0.50

Safety Profile0.50

Key Metrics

PDB Structures:

Known Drugs:

Approved:

In Clinical Trials:

Drug Pipeline (1 compounds)

1 Preclinical

Mechanism: Prioritized from 1 SciDEX hypotheses, including: Programmable Neuronal Circuit Repair via Epigenetic CRISPR

Drug Pipeline (1 compounds)

1 Preclinical

Known Drugs:

CHEMBL4854333 (preclinical)

Structural Data:

PDB —AlphaFold ✓Cryo-EM —

UniProt: P43354

🧬 3D Protein Structure

🧬 NURR1 — PDB 1OVL Click to expand interactive 3D viewer

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

3D Protein Structure (AlphaFold)

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AlphaFold predicted structure available for P43354

View AlphaFold Structure

Linked Hypotheses (0)

No linked hypotheses

Linked Experiments (0)

No linked experiments

Scoring Dimensions

Knowledge Graph (20)

activates (7)

NURR1→GFAPNURR1→LAMP1NURR1→LAMP2NURR1→CTSDNURR1→VMAT2

▸ Show 2 more

NURR1→MTORPARKIN→NURR1

co discussed (12)

Cell-type-specific essential genes→NURR1APOE regulatory regions→NURR1NURR1→FOXO3NURR1→PGC1ANURR1→BDNF

▸ Show 7 more

NURR1→LDLRNURR1→HTTNURR1→SIRT1NURR1→APOENURR1→repeat-containing transcriptsNURR1→PITX3NURR1→DMPK

inhibits (1)

NURR1→GBA

Debate History (1)

Should NURR1 (NURR1 Protein) be prioritized as a therapeutic target for neurodeg2026-04-26