gene

ASCL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ASCL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

126Connections

0Hypotheses

0Analyses

50Outgoing

27Incoming

0Experiments

0Debates

Summary

A gene referenced in 117 knowledge graph relationships. Key connections: regulates SEZ6 (protein); activates Carcinoma (disease); activates Cancer (disease).

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🧬 Gene Info

Gene Symbol	ASCL1
Full Name	Achaete-Scute Homolog 1
Chromosome	12p23.2
Protein Type	Transcription Factor
Function	is a basic helix-loop-helix (bHLH) transcription factor essential for neural development, neurogenesis, and the differentiation of specific neuronal lineages.
Primary Expression	multiple developmental contexts:
Molecular Weight	26.8 kDa
Amino Acids	237 aa
UniProt ID	P50567
NCBI Gene ID	41
Ensembl ID	ENSG00000139352
OMIM	100800
GeneCards	ASCL1
Human Protein Atlas	ASCL1
Canonical E-box	CANNTG (preferred: CAGCTG, CACGTG)
Associated Diseases	Cancer, Lung Cancer, Tumor
Interactions	AND, BCL2, Bdnf, BDNF, CANCER, DNA
KG Connections	118 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ASCL1 Gene

gene · 1761 words

→

ASCL1 Protein

protein · 599 words

→

Pathway Diagram

flowchart TD
    A["ASCL1"] --> B["Neurogenesis"]
    A --> C["Neuronal Differentiation"]
    A --> D["Direct Reprogramming"]
    B --> E["Neural Progenitor Cells"]
    C --> F["SEZ6 Expression"]
    E --> G["New Neuron Generation"]
    F --> H["Neuronal Excitability"]
    G --> I["Brain Repair"]
    D --> J["Glia to Neuron Conversion"]
    J --> I
    H --> I

Outgoing (99)

Target	Relation	Type	Str
SEZ6	regulates	protein	0.70
Bipolar	activates	disease	0.65
Ms	activates	disease	0.65
Carcinoma	regulates	disease	0.65
Tumor	associated_with	disease	0.65
Schizophrenia	activates	disease	0.65
ALS	activates	disease	0.65
neurons	expressed_in	cell_type	0.65
Aging	activates	disease	0.65
Als	activates	disease	0.65
Depression	activates	disease	0.65
Parkinson	inhibits	disease	0.65
Prostate Cancer	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Neuropathy	regulates	disease	0.65
Carcinoma	activates	disease	0.65
Cancer	activates	disease	0.65
Diabetes	regulates	disease	0.65
Als	regulates	disease	0.65
Cancer	associated_with	disease	0.65
Lung Cancer	associated_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	expressed_in	disease	0.65
Gdnf	activates	protein	0.60
RB1	therapeutic_target	gene	0.60
SOX2	therapeutic_target	gene	0.60
FOXA2	regulates	gene	0.60
Rb	therapeutic_target	protein	0.60
LHX6	regulates	gene	0.60
NEUROD1	interacts_with	gene	0.60
NOTCH1	interacts_with	gene	0.60
NOTCH1	activates	gene	0.60
STING	activates	gene	0.60
GBM	regulates	gene	0.60
OLIG2	regulates	gene	0.60
GBM	activates	gene	0.60
OLIG2	activates	gene	0.60
OLIG2	interacts_with	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
CANCER	expressed_in	gene	0.60
DNA	activates	gene	0.60
Dna Methylation	activates	pathway	0.60
Apoptosis	expressed_in	pathway	0.60
Epithelial-Mesenchymal Transition	activates	pathway	0.60
CANCER	associated_with	gene	0.60
GENES	activates	gene	0.60
Epigenetic	regulates	pathway	0.60
MYCN	regulates	gene	0.60
RNA	activates	gene	0.60
KDM6A	activates	gene	0.60

Incoming (27)

Source	Relation	Type	Str
NGF	activates	gene	0.60
UBIQUITIN	inhibits	gene	0.60
PTEN	therapeutic_target	gene	0.60
TP53	therapeutic_target	gene	0.60
EZH2	therapeutic_target	gene	0.60
SYP	therapeutic_target	gene	0.60
TRPV1	regulates	gene	0.60
CANCER	activates	gene	0.60
GENES	inhibits	gene	0.60
P53	activates	gene	0.60
PARKINSON	inhibits	gene	0.60
IL-1	regulates	gene	0.60
RNA	regulates	gene	0.60
NGN2	associated_with	gene	0.60
DISC1	associated_with	gene	0.60
YAP1	associated_with	gene	0.60
HNF4A	regulates	gene	0.60
NEUROD1	associated_with	gene	0.60
LMX1A	activates	gene	0.60
PRKN	activates	gene	0.60
PARKIN	inhibits	gene	0.60
GDNF	activates	gene	0.60
BDNF	activates	gene	0.60
NURR1	activates	gene	0.60
YAP	activates	gene	0.60
AND	associated_with	gene	0.60
CANCER	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ASCL1 in their description or question text

No additional research found