Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about VMAT2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
VMAT2 is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Inflammation, Neuroinflammation, Parkinson. Connected to 16 entities in the SciDEX knowledge graph.
No AI portrait yet
| Gene Symbol | VMAT2 |
| Full Name | Vesicular Monoamine Transporter 2 |
| Chromosome | 10q25.2 |
| Function | VMAT2 mediates vesicular uptake of monoamines |
| Primary Expression | all monoaminergic neurons (dopaminergic, serotonergic, noradrenergic) |
| Molecular Weight | 56 kDa |
| Amino Acids | 525 aa |
| Exons | 18 |
| Pathways | Autophagy, Mapk, Mtor |
| NCBI Gene ID | 6844 |
| Ensembl ID | ENSG00000165646 |
| OMIM | 193001 |
| GeneCards | VMAT2 |
| Human Protein Atlas | VMAT2 |
| Associated Diseases | Parkinson's disease |
| Known Drugs/Compounds | levodopa |
| Interactions | ALPHA-SYNUCLEIN, AMPK, AUTOPHAGY, DAT, MTOR, NEUROINFLAMMATION |
| KG Connections | 28 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
VMAT2["VMAT2"]
Neuroinflammation{"Neuroinflammation"}
VMAT2 -->|"activates"| Neuroinflammation
Parkinson{"Parkinson"}
VMAT2 -->|"activates"| Parkinson
Inflammation{"Inflammation"}
VMAT2 -->|"activates"| Inflammation
NEURON["NEURON"]
VMAT2 -->|"activates"| NEURON
NEUROINFLAMMATION["NEUROINFLAMMATION"]
VMAT2 -->|"activates"| NEUROINFLAMMATION
MTOR["MTOR"]
VMAT2 -->|"activates"| MTOR
Mtor(["Mtor"])
VMAT2 -->|"activates"| Mtor
Autophagy(["Autophagy"])
VMAT2 -->|"activates"| Autophagy
Mapk(["Mapk"])
VMAT2 -->|"activates"| Mapk
AUTOPHAGY["AUTOPHAGY"]
AUTOPHAGY -->|"activates"| VMAT2
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
PARKINSON_S_DISEASE -->|"activates"| VMAT2
AMPK["AMPK"]
AMPK -->|"activates"| VMAT2
PARKINSON["PARKINSON"]
PARKINSON -->|"activates"| VMAT2
NURR1["NURR1"]
NURR1 -->|"activates"| VMAT2
ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
ALPHA_SYNUCLEIN -->|"activates"| VMAT2| Target | Relation | Type | Str |
|---|---|---|---|
| Neuroinflammation | activates | disease | 0.65 |
| Parkinson | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Mtor | activates | pathway | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| Mapk | activates | pathway | 0.60 |
| Parkinson's disease | regulates | disease | 0.60 |
| Parkinson's disease | interacts_with | disease | 0.60 |
| MTOR | activates | gene | 0.60 |
| Parkinson's disease | associated_with | disease | 0.60 |
| NEURON | activates | gene | 0.60 |
| NEUROINFLAMMATION | activates | gene | 0.60 |
| dopaminergic neurons | expressed_in | cell_type | 0.55 |
| neurons | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| entities-overview | associated_with | wiki | 0.00 |
| genes-vmat2 | documents | wiki_page | 1.00 |
| NURR1 | activates | gene | 0.60 |
| ALPHA-SYNUCLEIN | activates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| PARKINSON'S DISEASE | activates | gene | 0.60 |
| AMPK | activates | gene | 0.60 |
| PARKINSON | activates | gene | 0.60 |
| DAT | interacts_with | gene | 0.60 |
| DAT | associated_with | gene | 0.60 |
| DAT | regulates | gene | 0.55 |
| NURR1 | regulates | gene | 0.55 |
| TH | regulates | gene | 0.55 |
| levodopa | targets | drug | 0.55 |
| AADC | regulates | gene | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning VMAT2 in their description or question text
No additional research found