concept

HO1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HO1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

133Connections

0Hypotheses

0Analyses

50Outgoing

37Incoming

0Experiments

0Debates

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💡 Concept Info

Name	HO1
Key Genes/Proteins	ACSL4, AD, AIM2, ALOX12, ALZHEIMER, ALZHEIMER'S DISEASE
Related Diseases	Addiction, Aging, ALS, Alzheimer, Anxiety
Related Pathways	Amyloid

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Heme Oxygenase-1 (HO-1)

protein · 1218 words

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Pathway Diagram

graph TD
    HO1["HO1"]
    HO1 -->|"regulates"| Alzheimer["Alzheimer"]
    HO1 -->|"target for"| Addiction["Addiction"]
    HO1 -->|"target for"| Depression["Depression"]
    HO1 -->|"target for"| Stroke["Stroke"]
    HO1 -->|"target for"| Parkinson["Parkinson"]
    HO1 -->|"target for"| Epilepsy["Epilepsy"]
    HO1 -->|"target for"| Anxiety["Anxiety"]
    Ric["Ric"] -->|"upregulates"| HO1
    NFE2L2["NFE2L2"] -->|"regulates"| HO1
    NRF2["NRF2"] -->|"activates"| HO1
    ALZHEIMER["ALZHEIMER"] -->|"regulates"| HO1
    MICROGLIA["MICROGLIA"] -->|"regulates"| HO1

Outgoing (96)

Target	Relation	Type	Str
NRF2	expresses	gene	0.70
MICROGLIA	activates	cell_type	0.70
TNF	activates	gene	0.70
NEURONS	activates	cell_type	0.70
KEAP1	associated_with	gene	0.70
Inflammation	regulates	disease	0.65
ALS	regulates	disease	0.65
Aging	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Inflammation	associated_with	disease	0.65
Addiction	therapeutic_target	disease	0.65
Dementia	associated_with	disease	0.65
Alzheimer	regulates	disease	0.65
Stroke	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Depression	therapeutic_target	disease	0.65
Anxiety	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Epilepsy	therapeutic_target	disease	0.65
ALZHEIMER	therapeutic_target	gene	0.60
STROKE	therapeutic_target	gene	0.60
IL-6	therapeutic_target	gene	0.60
DEPRESSION	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
EPILEPSY	therapeutic_target	gene	0.60
ANXIETY	therapeutic_target	gene	0.60
Nf-Κb	therapeutic_target	pathway	0.60
Pi3K/Akt	therapeutic_target	pathway	0.60
Bdnf	associated_with	protein	0.60
Cytokine	therapeutic_target	protein	0.60
Sod1	associated_with	protein	0.60
oxidative stress response	participates_in	pathway	0.60
NRF2	inhibits	gene	0.60
NEURON	enhances	cell_type	0.60
NRF2	biomarker_for	gene	0.60
NRF2	activates	gene	0.60
DMT1	regulates	gene	0.60
NQO1	activates	gene	0.60
AIM2	regulates	gene	0.60
SOD3	activates	gene	0.60
ROS	activates	gene	0.60
neurons	expressed_in	cell_type	0.60
SIRT1	inhibits	gene	0.60
NRF2	associated_with	gene	0.60
ARG1	associated_with	gene	0.60
PTGS1	associated_with	gene	0.60
OXIDATIVE STRESS	markers	pathway	0.60
OXIDATIVE STRESS	activates	pathway	0.60
SLC40A1	associated_with	gene	0.60
Microglia	regulates	cell_type	0.60

Incoming (37)

Source	Relation	Type	Str
Ric	upregulates	process	0.92
NRF2	activates	protein	0.90
NFE2L2	regulates	gene	0.90
NFE2L2	upregulates	gene	0.85
NRF2	upregulates	gene	0.80
CYP46A1	expresses	gene	0.70
ALZHEIMER	regulates	gene	0.60
DEMENTIA	associated_with	gene	0.60
MICROGLIA	regulates	gene	0.60
APOPTOSIS	associated_with	gene	0.60
GPX4	inhibits	gene	0.60
VEGF	associated_with	gene	0.60
FSP1	regulates	gene	0.60
GPX4	regulates	gene	0.60
CYTOKINES	associated_with	gene	0.60
GSH	associated_with	gene	0.60
FERROPTOSIS	co_discussed	pathway	0.60
FERROPTOSIS	inhibits	pathway	0.60
CD163	biomarker_for	gene	0.60
CD206	biomarker_for	gene	0.60
CD36	biomarker_for	gene	0.60
GPX4	biomarker_for	gene	0.60
GFAP	associated_with	gene	0.60
GPX4	associated_with	gene	0.60
GSH	biomarker_for	gene	0.60
AΒ	activates	gene	0.60
ACSL4	biomarker_for	gene	0.60
AD	activates	gene	0.60
ARG1	associated_with	gene	0.60
ALOX12	associated_with	gene	0.60
NRF2	associated_with	gene	0.60
GSH	activates	gene	0.60
AR	associated_with	gene	0.60
BAX	associated_with	gene	0.60
BDNF	co_discussed	gene	0.40
GPX4	co_discussed	gene	0.40
GFAP	co_discussed	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HO1 in their description or question text

No additional research found