protein 1,982 words KG: NQO1
Contents

NQO1 Protein (NAD(P)H Quinone Dehydrogenase 1)

🔬 Protein Info
Gene SymbolNQO1
Full NameNAD(P)H Quinone Dehydrogenase 1
AliasesNAD(P
Chromosome16q22.1
FunctionNQO1 uses NAD(P)H as an electron donor to reduce quinones, preventing the formation of toxic semiquinone radicals.
Subcellular Localization** | Cytoplasm, also nucleus (minor) |
Molecular Weight31 kDa
Amino Acids274 aa
PathwaysApoptosis, Ferroptosis
UniProt IDP15559
NCBI Gene ID1728
Ensembl IDENSG00000100119
OMIM125860
GeneCardsNQO1
Human Protein AtlasNQO1
Associated DiseasesInflammation, Senescence
InteractionsAKT, ALZHEIMER, ALZHEIMER'S DISEASE, AND, ANTIOXIDANT GENES, APOPTOSIS
KG Connections278 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (7)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62

Related Analyses (6)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Sirtuin Pathway Dysfunction Validation in Parkinson's Diseas
clinical · proposed · Score: 0.40

See Also (7)

Ferroptosis Validation in Parkinson's Disease
experiment · KG edge: inhibits
ASC (PYCARD)
gene · KG edge: expressed_in
BAX Gene
gene · KG edge: activates
BDNF Gene
gene · KG edge: associated_with
FSP1 Gene - Ferroptosis Suppressor Protein 1
gene · KG edge: inhibits

Knowledge Graph (12 edges)

NRF2 regulates NQO1
NQO1 regulates HMOX1
NQO1 regulates TXNRD1
NQO1 regulates NRF2
NQO1 regulates GCLM
NQO1 regulates GCLC
NQO1 activates GCLC
NQO1 activates TNF
NQO1 activates PI3K
NQO1 activates NRF2

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