protein

SRXN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SRXN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

69Connections

0Hypotheses

0Analyses

39Outgoing

30Incoming

0Experiments

0Debates

Summary

SRXN1 is a protein involved in neurodegeneration research. Key relationships include: biomarker for, activates, regulates. Associated with Als, Breast Cancer, Cancer. Connected to 40 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	SRXN1
Function	SRXN1 (Sulfiredoxin 1) is a small antioxidant enzyme (125 amino acids) specialized in reducing overoxidized peroxiredoxins (Prxs). It catalyzes the ATP-dependent reduction of cysteine-sulfinic acid...
Amino Acids	125 aa
Pathways	Oxidative Stress, Ferroptosis, Mtor, Oxidative Phosphorylation, Immune Response
GeneCards	SRXN1
Human Protein Atlas	SRXN1
Associated Diseases	Inflammation, Lymphoma, Tumor
Interactions	CANCER, GENES, KEAP1, NRF2, OXIDATIVE STRESS, SLC7A11
KG Connections	69 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

SRXN1 Protein

protein · 612 words

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Pathway Diagram

graph TD
    SRXN1["SRXN1"]
    Inflammation{"Inflammation"}
    SRXN1 -->|"biomarker for"| Inflammation
    SRXN1 -->|"associated with"| Inflammation
    Lymphoma{"Lymphoma"}
    SRXN1 -->|"associated with"| Lymphoma
    Ms{"Ms"}
    SRXN1 -->|"biomarker for"| Ms
    Tumor{"Tumor"}
    SRXN1 -->|"associated with"| Tumor
    Oxidative_Stress(["Oxidative Stress"])
    SRXN1 -->|"biomarker for"| Oxidative_Stress
    SRXN1 -->|"associated with"| Oxidative_Stress
    BRD4["BRD4"]
    SRXN1 -->|"biomarker for"| BRD4
    ATM["ATM"]
    SRXN1 -->|"biomarker for"| ATM
    PRDX1["PRDX1"]
    SRXN1 -->|"biomarker for"| PRDX1
    Ferroptosis(["Ferroptosis"])
    SRXN1 -->|"associated with"| Ferroptosis
    Mtor(["Mtor"])
    SRXN1 -->|"biomarker for"| Mtor
    NRF2["NRF2"]
    NRF2 -->|"regulates"| SRXN1
    NQO1["NQO1"]
    NQO1 -->|"regulates"| SRXN1
    GCLC["GCLC"]
    GCLC -->|"regulates"| SRXN1
    GCLM["GCLM"]
    GCLM -->|"regulates"| SRXN1
    HMOX1["HMOX1"]
    HMOX1 -->|"regulates"| SRXN1
    GENES["GENES"]
    GENES -->|"biomarker for"| SRXN1
    TXNRD1["TXNRD1"]
    TXNRD1 -->|"regulates"| SRXN1
    MTOR["MTOR"]
    MTOR -->|"biomarker for"| SRXN1
    FERROPTOSIS["FERROPTOSIS"]
    FERROPTOSIS -->|"associated with"| SRXN1
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    OXIDATIVE_STRESS -->|"biomarker for"| SRXN1
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"biomarker for"| SRXN1
    AND["AND"]
    AND -->|"regulates"| SRXN1
    style SRXN1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (39)

Target	Relation	Type	Str
DLBCL	biomarker_for	disease	0.80
Inflammation	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Tumor	associated_with	disease	0.65
Lymphoma	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Tumor	activates	disease	0.65
Breast Cancer	activates	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Oxidative Stress	activates	pathway	0.60
GCLM	regulates	gene	0.60
HMOX1	regulates	gene	0.60
TXNRD1	regulates	gene	0.60
INFLAMMATION	biomarker_for	gene	0.60
AND	regulates	gene	0.60
GENES	biomarker_for	gene	0.60
oxidative stress response	participates_in	pathway	0.60
Fus	associated_with	protein	0.60
App	associated_with	protein	0.60
Oxidative Stress	biomarker_for	pathway	0.60
Cell Cycle	associated_with	pathway	0.60
FERROPTOSIS	associated_with	gene	0.60
PRDX1	biomarker_for	gene	0.60
Ferroptosis	associated_with	pathway	0.60
Mtor	biomarker_for	pathway	0.60
Oxidative Phosphorylation	associated_with	pathway	0.60
NQO1	regulates	gene	0.60
Immune Response	associated_with	pathway	0.60
BRD4	biomarker_for	gene	0.60
ATM	biomarker_for	gene	0.60
SAT1	biomarker_for	gene	0.60
MTOR	biomarker_for	gene	0.60
RNA	associated_with	gene	0.60
OXIDATIVE STRESS	biomarker_for	gene	0.60
Oxidative Stress	associated_with	pathway	0.60
NRF2	regulates	gene	0.60
GCLC	regulates	gene	0.60
PRDX1	associated_with	protein	0.50

Incoming (30)

Source	Relation	Type	Str
NRF2	regulates	protein	0.82
BRD4	biomarker_for	gene	0.60
AND	biomarker_for	gene	0.60
SAT1	biomarker_for	gene	0.60
ACO1	biomarker_for	gene	0.60
LPIN1	biomarker_for	gene	0.60
MT1G	biomarker_for	gene	0.60
PEBP1	biomarker_for	gene	0.60
OXIDATIVE STRESS	biomarker_for	gene	0.60
INFLAMMATION	biomarker_for	gene	0.60
SLC7A11	activates	gene	0.60
KEAP1	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
CANCER	activates	gene	0.60
GENES	activates	gene	0.60
NRF2	activates	gene	0.60
AND	regulates	gene	0.60
ATM	biomarker_for	gene	0.60
PRDX1	biomarker_for	gene	0.60
RNA	associated_with	gene	0.60
FERROPTOSIS	associated_with	gene	0.60
TXNRD1	regulates	gene	0.60
MTOR	biomarker_for	gene	0.60
NQO1	regulates	gene	0.60
GCLC	regulates	gene	0.60
GCLM	regulates	gene	0.60
HMOX1	regulates	gene	0.60
GENES	biomarker_for	gene	0.60
BRD4	associated_with	gene	0.50
mTOR	associated_with	entity	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SRXN1 in their description or question text

No additional research found