gene

GCLC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GCLC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

131Connections

0Hypotheses

0Analyses

50Outgoing

46Incoming

0Experiments

0Debates

Summary

GCLC is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in, regulates. Associated with Als, Autoimmune, Infection. Connected to 74 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GCLC
Aliases	Glutamate-Cysteine Ligase Catalytic Subunit
Chromosome	6p12.3
Molecular Weight	73 kDa
Amino Acids	637 aa
Pathways	oxidative stress response, Oxidative Stress, Akt, Pi3K, Nf-Κb
Ensembl ID	ENSG00000001036
GeneCards	GCLC
Human Protein Atlas	GCLC
Nrf2/ARE pathway	Primary transcriptional activator
AP-1 transcription factor	Induced by oxidative stress
NF-κB	Can both activate and repress depending on context
mRNA stability	Affected by redox state
Alternative splicing	Produces variant isoforms
Feedback inhibition	GSH inhibits GCLC activity
Associated Diseases	Alzheimer, Infection, Inflammation
Interactions	ACSL4, Actin, AKT, ALZHEIMER, AND, ARF1
KG Connections	131 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GCLC["GCLC"]
    Inflammation{"Inflammation"}
    GCLC -->|"biomarker for"| Inflammation
    GCLC -->|"activates"| Inflammation
    Obesity{"Obesity"}
    GCLC -->|"activates"| Obesity
    GCLC -->|"associated with"| Inflammation
    Als{"Als"}
    GCLC -->|"activates"| Als
    Ms{"Ms"}
    GCLC -->|"activates"| Ms
    Oxidative_Stress(["Oxidative Stress"])
    GCLC -->|"biomarker for"| Oxidative_Stress
    GCLM["GCLM"]
    GCLC -->|"regulates"| GCLM
    HMOX1["HMOX1"]
    GCLC -->|"regulates"| HMOX1
    GENES["GENES"]
    GCLC -->|"biomarker for"| GENES
    NRF2["NRF2"]
    GCLC -->|"regulates"| NRF2
    TXNRD1["TXNRD1"]
    GCLC -->|"regulates"| TXNRD1
    NRF2 -->|"regulates"| GCLC
    NQO1["NQO1"]
    NQO1 -->|"regulates"| GCLC
    HMOX1 -->|"regulates"| GCLC
    TXNRD1 -->|"regulates"| GCLC
    GCLM -->|"regulates"| GCLC
    NQO1 -->|"activates"| GCLC
    TFRC["TFRC"]
    TFRC -->|"activates"| GCLC
    SLC7A11["SLC7A11"]
    SLC7A11 -->|"activates"| GCLC
    ERK["ERK"]
    ERK -->|"activates"| GCLC
    P38["P38"]
    P38 -->|"activates"| GCLC
    GPX4["GPX4"]
    GPX4 -->|"activates"| GCLC
    ACSL4["ACSL4"]
    ACSL4 -->|"activates"| GCLC
    style GCLC fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (85)

Target	Relation	Type	Str
Glutathione	involved_in	compound	0.95
Obesity-Related Tumor Progression	suppresses	process	0.90
Glutathione	regulates	compound	0.90
Inflammation	activates	disease	0.75
oxidative stress response	participates_in	pathway	0.70
Infection	implicated_in	disease	0.65
Autoimmune	inhibits	disease	0.65
Inflammation	associated_with	disease	0.65
Obesity	activates	disease	0.65
Als	activates	disease	0.65
Obesity	inhibits	disease	0.65
Cancer	activates	disease	0.65
Tumor	inhibits	disease	0.65
Ms	activates	disease	0.65
Alzheimer	activates	disease	0.65
Fibrosis	activates	disease	0.65
Aging	activates	disease	0.65
Inflammation	biomarker_for	disease	0.65
Oxidative Stress	associated_with	pathway	0.60
Ferroptosis	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
Necroptosis	activates	pathway	0.60
APOPTOSIS	therapeutic_target	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
Apoptosis	therapeutic_target	pathway	0.60
Oxidative Stress	therapeutic_target	pathway	0.60
INFLAMMATION	biomarker_for	gene	0.60
OXIDATIVE STRESS	biomarker_for	gene	0.60
GSH	inhibits	gene	0.60
TNF-Α	activates	gene	0.60
GSH	associated_with	gene	0.60
PI3K	activates	gene	0.60
NRF2	activates	gene	0.60
AKT	activates	gene	0.60
NQO1	regulates	gene	0.60
HSPA1A	associated_with	gene	0.60
Oxidative Stress	biomarker_for	pathway	0.60
GENES	biomarker_for	gene	0.60
SRXN1	regulates	gene	0.60
Oxidative Stress	activates	pathway	0.60
Nf-Κb	activates	pathway	0.60
TNF	activates	gene	0.60
MTOR	implicated_in	gene	0.60
ARF1	activates	gene	0.60
Rb	activates	protein	0.60
GCLM	activates	gene	0.60
GR	activates	gene	0.60
PCBP2	targets	gene	0.60
PEX13	targets	gene	0.60
PPP1CA	targets	gene	0.60

Incoming (46)

Source	Relation	Type	Str
NRF2	regulates	protein	0.72
AND	associated_with	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
GENES	associated_with	gene	0.60
NQO1	regulates	gene	0.60
HMOX1	regulates	gene	0.60
TXNRD1	regulates	gene	0.60
GCLM	regulates	gene	0.60
TFRC	activates	gene	0.60
SLC7A11	activates	gene	0.60
P38	activates	gene	0.60
GPX4	activates	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
ACSL4	activates	gene	0.60
MIRNAS	associated_with	gene	0.60
AND	regulates	gene	0.60
GSH	inhibits	gene	0.60
TNF	activates	gene	0.60
BECN1	targets	gene	0.60
CYP27B1	targets	gene	0.60
OXIDATIVE STRESS	biomarker_for	gene	0.60
GENES	biomarker_for	gene	0.60
INFLAMMATION	biomarker_for	gene	0.60
SRXN1	regulates	gene	0.60
NQO1	activates	gene	0.60
ICAM1	associated_with	gene	0.60
HSP70	associated_with	gene	0.60
HSPA1A	associated_with	gene	0.60
AKT	activates	gene	0.60
NRF2	activates	gene	0.60
ERK	activates	gene	0.60
GENES	activates	gene	0.60
MTORC1	activates	gene	0.60
CANCER	activates	gene	0.60
AND	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
HO-1	activates	gene	0.60
NF-ΚB	activates	gene	0.60
ROS	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
IL-6	activates	gene	0.60
MTOR	activates	gene	0.60
SCARB2	activates	gene	0.60
ARF1	activates	gene	0.60
AKT	co_expressed_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GCLC in their description or question text

No additional research found