protein

MECP2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MECP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

242Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

Methyl-CpG Binding Protein 2 (MECP2) is a transcriptional regulator critical for neuronal development and function. MECP2 mutations cause Rett syndrome and are implicated in MECP2 duplication syndrome and other neuropsychiatric disorders.

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	MECP2
Full Name	Methyl-CpG Binding Protein 2
Protein Family	Methyl-CpG binding domain (MBD) family
Function	In neurons, MeCP2 binds broadly across the genome, preferentially at methylated CpG dinucleotides and non-CpG methylation sites (particularly mCA), which are highly abundant in mature neurons [@birdse
Primary Expression	Cerebral cortex, Hippocampus, Cerebellum, Brainstem, Basal ganglia, Thalamus
Subcellular Localization	Nucleus (chromatin-associated)
Molecular Weight	53 kDa
Amino Acids	80 aa
Pathways	Akt, Epigenetic, Mapk, Mitophagy
UniProt ID	P51608
Ensembl ID	ENSG00000169057
GeneCards	MECP2
Human Protein Atlas	MECP2
Associated Diseases	Als, Autism, epilepsy, Rett syndrome
Interactions	Actin, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-BETA, AND
KG Connections	239 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: MECP2 — AlphaFold P51608 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

MECP2 — Methyl-CpG Binding Protein 2

gene · 1655 words

→

MECP2 Protein

protein · 940 words

→

Pathway Diagram

graph TD
    MECP2["MECP2"] -->|"regulates"| MMP9["MMP9"]
    MECP2["MECP2"] -->|"interacts"| SIRT1["SIRT1"]
    MECP2["MECP2"] -->|"causes"| Rett_syndrome["Rett syndrome"]
    MECP2["MECP2"] -->|"regulates"| BDNF["BDNF"]
    MECP2["MECP2"] -.->|"inhibits"| Ms["Ms"]
    MECP2["MECP2"] -.->|"inhibits"| Depression["Depression"]
    FUS["FUS"] -->|"regulates"| MECP2["MECP2"]
    NRBP1["NRBP1"] -.->|"inhibits"| MECP2["MECP2"]
    BDNF_1["BDNF"] -->|"activates"| MECP2["MECP2"]
    CSF1R["CSF1R"] -.->|"inhibits"| MECP2["MECP2"]
    style MECP2 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (159)

Target	Relation	Type	Str
APOPTOSIS	represses	process	0.80
SYP	co_expressed_with	protein	0.75
MMP9	regulates	protein	0.70
BDNF	regulates	protein	0.70
SIRT1	interacts_with	protein	0.70
Rett syndrome	causes	disease	0.70
Neuronal dysfunction	causes	phenotype	0.70
5hmC binding	targets	mechanism	0.70
Ischemia	activates	disease	0.65
Stroke	regulates	disease	0.65
ALS	activates	disease	0.65
Epilepsy	therapeutic_target	disease	0.65
Aging	regulates	disease	0.65
Als	inhibits	disease	0.65
Epilepsy	encodes	disease	0.65
Als	associated_with	disease	0.65
Ms	expressed_in	disease	0.65
Depression	inhibits	disease	0.65
Ms	regulates	disease	0.65
ALS	expressed_in	disease	0.65
Cancer	regulates	disease	0.65
Als	regulates	disease	0.65
Tumor	regulates	disease	0.65
Ms	inhibits	disease	0.65
Autism	associated_with	disease	0.65
Alzheimer	activates	disease	0.65
Als	expressed_in	disease	0.65
Depression	activates	disease	0.65
Als	activates	disease	0.65
Aging	activates	disease	0.65
Epilepsy	causes	disease	0.65
Cancer	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
Apoptosis	therapeutic_target	pathway	0.60
Microglia	activates	cell_type	0.60
Neuron	inhibits	cell_type	0.60
Astrocyte	inhibits	cell_type	0.60
AND	inhibits	gene	0.60
NGF	regulates	protein	0.60
GENES	inhibits	gene	0.60
HDAC3	regulates	gene	0.60
CSF1R	inhibits	gene	0.60
DDX3X	associated_with	gene	0.60
CANCER	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
G3BP1	therapeutic_target	gene	0.60
CASP3	activates	gene	0.60
RPS6KB1	regulates	gene	0.60
HDAC1	regulates	gene	0.60
JUN	regulates	gene	0.60

Incoming (83)

Source	Relation	Type	Str
FUS	regulates	protein	0.80
CREB	interacts_with	protein	0.70
NT4	activates	gene	0.60
FLAVONOIDS	therapeutic_target	gene	0.60
NATURAL COMPOUNDS	therapeutic_target	gene	0.60
NRBP1	inhibits	gene	0.60
BDNF	activates	gene	0.60
CSF1R	inhibits	gene	0.60
KCNQ3	regulates	gene	0.60
EGFR	regulates	gene	0.60
HDAC2	regulates	gene	0.60
IGF2BP1	therapeutic_target	gene	0.60
EWSR1	therapeutic_target	gene	0.60
YBX1	therapeutic_target	gene	0.60
BNIP3L	expressed_in	gene	0.60
IL6	regulates	gene	0.60
FAS	activates	gene	0.60
MAPK1	regulates	gene	0.60
IL1B	regulates	gene	0.60
MYC	regulates	gene	0.60
AKT	regulates	gene	0.60
KCNQ2	regulates	gene	0.60
CALCINEURIN	activates	gene	0.60
MIRNAS	contributes_to	gene	0.60
GENES	expressed_in	gene	0.60
MIR-155	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
MICRORNAS	expressed_in	gene	0.60
HDAC3	regulates	entity	0.60
PLA2G6	inhibits	gene	0.60
HTT	activates	gene	0.60
HUNTINGTIN	regulates	gene	0.60
HUNTINGTIN	phosphorylates	gene	0.60
NGF	associated_with	gene	0.60
POLE	causes	gene	0.60
POLE	encodes	gene	0.60
ERK	activates	gene	0.60
DNA	inhibits	gene	0.60
DEPRESSION	inhibits	gene	0.60
RNA	inhibits	gene	0.60
EPILEPSY	therapeutic_target	gene	0.60
POLE	therapeutic_target	gene	0.60
NEURON	inhibits	gene	0.60
ERK	inhibits	gene	0.60
MICROGLIA	activates	gene	0.60
ASTROCYTE	inhibits	gene	0.60
CREB	activates	gene	0.60
AND	activates	gene	0.60
EPILEPSY	causes	gene	0.60
AND	associated_with	gene	0.60