Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KCNQ2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
KCNQ2 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, regulates, activates. Associated with Aging, Als, Autism. Connected to 44 entities in the SciDEX knowledge graph.
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| Gene Symbol | KCNQ2 |
| Aliases | Kv7.2 |
| Chromosome | 20q13.33 |
| Function | is a non-inactivating K+ current that activates at voltages near the threshold for action potential firing. |
| Primary Expression | Brain (neurons throughout forebrain, highest in cortex, hippocampus, brainstem) |
| Molecular Weight | 95 kDa |
| Amino Acids | 844 aa |
| UniProt ID | O43726 |
| NCBI Gene ID | 3785 |
| Ensembl ID | ENSG00000155085 |
| OMIM | 121200 |
| GeneCards | KCNQ2 |
| Human Protein Atlas | KCNQ2 |
| Associated Diseases | Aging |
| Interactions | CANCER, EGFR, ERK, RUNX1 |
| KG Connections | 67 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
KCNQ2["KCNQ2"]
Aging{"Aging"}
KCNQ2 -->|"therapeutic target"| Aging
Als{"Als"}
KCNQ2 -->|"therapeutic target"| Als
Neuroinflammation{"Neuroinflammation"}
KCNQ2 -->|"therapeutic target"| Neuroinflammation
Epilepsy{"Epilepsy"}
KCNQ2 -->|"therapeutic target"| Epilepsy
Autism{"Autism"}
KCNQ2 -->|"therapeutic target"| Autism
Ms{"Ms"}
KCNQ2 -->|"therapeutic target"| Ms
Inflammation{"Inflammation"}
KCNQ2 -->|"therapeutic target"| Inflammation
KCNQ2 -->|"regulates"| Als
Tumor{"Tumor"}
KCNQ2 -->|"activates"| Tumor
KCNQ2 -->|"regulates"| Ms
Cancer{"Cancer"}
KCNQ2 -->|"activates"| Cancer
KCNQ2 -->|"expressed in"| Ms
DHX9["DHX9"]
DHX9 -->|"therapeutic target"| KCNQ2
KCNT1["KCNT1"]
KCNT1 -->|"associated with"| KCNQ2
KCNQ3["KCNQ3"]
KCNQ3 -->|"regulates"| KCNQ2
EGFR["EGFR"]
EGFR -->|"activates"| KCNQ2
ERK["ERK"]
ERK -->|"activates"| KCNQ2
HDAC2["HDAC2"]
HDAC2 -->|"regulates"| KCNQ2
MECP2["MECP2"]
MECP2 -->|"regulates"| KCNQ2
CANCER["CANCER"]
CANCER -->|"activates"| KCNQ2
style KCNQ2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Kv7.2 | associated_with | protein | 0.95 |
| Als | regulates | disease | 0.65 |
| Aging | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Neuroinflammation | therapeutic_target | disease | 0.65 |
| Epilepsy | therapeutic_target | disease | 0.65 |
| Autism | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Inflammation | therapeutic_target | disease | 0.65 |
| Ms | expressed_in | disease | 0.65 |
| Aging | causes | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Aging | expressed_in | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| HDAC2 | regulates | gene | 0.60 |
| EGFR | activates | gene | 0.60 |
| KCNQ3 | regulates | gene | 0.60 |
| KCNT1 | associated_with | gene | 0.60 |
| DHX9 | therapeutic_target | gene | 0.60 |
| HCRT | regulates | gene | 0.60 |
| PLCB1 | associated_with | gene | 0.60 |
| SCN1A | associated_with | gene | 0.60 |
| SCN2A | associated_with | gene | 0.60 |
| EPILEPSY | therapeutic_target | gene | 0.60 |
| STXBP1 | associated_with | gene | 0.60 |
| WWOX | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| Mtor | therapeutic_target | pathway | 0.60 |
| Epigenetic | therapeutic_target | pathway | 0.60 |
| Synaptic Plasticity | therapeutic_target | pathway | 0.60 |
| ERK | activates | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| RUNX1 | activates | gene | 0.60 |
| SCN8A | associated_with | gene | 0.60 |
| NEUROINFLAMMATION | therapeutic_target | gene | 0.60 |
| NEURON | regulates | gene | 0.60 |
| AGING | expressed_in | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| Neuron | regulates | cell_type | 0.60 |
| RNA | causes | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| AGING | causes | gene | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| SCN1A | therapeutic_target | gene | 0.60 |
| MTOR | therapeutic_target | gene | 0.60 |
| RELN | therapeutic_target | gene | 0.60 |
| MECP2 | regulates | gene | 0.60 |
| Neuron | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TDP-43 | regulates | protein | 0.95 |
| CANCER | activates | gene | 0.60 |
| AGING | causes | gene | 0.60 |
| NEURON | regulates | gene | 0.60 |
| KCNQ3 | regulates | gene | 0.60 |
| EGFR | activates | gene | 0.60 |
| CDKL5 | associated_with | gene | 0.60 |
| ERK | activates | gene | 0.60 |
| HCN1 | associated_with | gene | 0.60 |
| DHX9 | therapeutic_target | gene | 0.60 |
| KCNT1 | associated_with | gene | 0.60 |
| HDAC2 | regulates | gene | 0.60 |
| MECP2 | regulates | gene | 0.60 |
| HCRT | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning KCNQ2 in their description or question text
No additional research found