| Gene Symbol | MECP2 |
| Protein Family | Methyl-CpG binding domain (MBD) family |
| Function | In neurons, MeCP2 binds broadly across the genome, preferentially at methylated CpG dinucleotides and non-CpG methylation sites (particularly mCA), which are highly abundant in mature neurons [@birdse |
| Primary Expression | Cerebral cortex, Hippocampus, Cerebellum, Brainstem, Basal ganglia, Thalamus |
| Subcellular Localization | Nucleus (chromatin-associated) |
| Molecular Weight | 53 kDa |
| Amino Acids | 80 aa |
| Pathways | Akt, Epigenetic, Mapk, Mitophagy |
| UniProt ID | P51608 |
| Ensembl ID | ENSG00000169057 |
| GeneCards | MECP2 |
| Human Protein Atlas | MECP2 |
| Associated Diseases | Als, Autism, epilepsy, Rett syndrome |
| Interactions | Actin, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-BETA, AND |
| KG Connections | 235 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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