gene

YBX1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about YBX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

148Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

YBX1 is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with Als, Cancer, Carcinoma. Connected to 76 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	YBX1
Full Name	Y-Box Binding Protein 1
Chromosome	1p34.2
Function	is a multifunctional DNA- and RNA-binding protein that plays critical roles in transcriptional regulation, mRNA splicing, translation, and stress response.
Primary Expression	the CNS: - High expression in neurons throughout the brain - Present in astrocytes and [microglia](/c
Subcellular Localization	and function
Molecular Weight	36 kDa
Amino Acids	70 aa
Pathways	Glycolysis, Multidrug Resistance, Nf-Κb, Wnt, mRNA Stability
UniProt ID	P62962
NCBI Gene ID	5102
Ensembl ID	ENSG00000165996
OMIM	113703
GeneCards	YBX1
Human Protein Atlas	YBX1
Associated Diseases	Cancer
Known Drugs/Compounds	m5C, m5C-modified mRNAs, SU056
Interactions	ABCB1, AGO2, AKT, ALYREF, AND, App
KG Connections	148 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: YBX1 — AlphaFold P62962 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

YBX1 Gene

gene · 915 words

→

YBX1 Protein

protein · 930 words

→

Pathway Diagram

graph TD
    YBX1["YBX1"]
    LRP1["LRP1"]
    YBX1 -->|"activates"| LRP1
    YBX1 -->|"regulates"| LRP1
    Cancer{"Cancer"}
    YBX1 -->|"activates"| Cancer
    Carcinoma{"Carcinoma"}
    YBX1 -->|"activates"| Carcinoma
    Tumor{"Tumor"}
    YBX1 -->|"activates"| Tumor
    Ms{"Ms"}
    YBX1 -->|"activates"| Ms
    YBX1 -->|"therapeutic target"| Carcinoma
    Als{"Als"}
    YBX1 -->|"regulates"| Als
    YBX1 -->|"regulates"| Tumor
    YBX1 -->|"associated with"| Cancer
    YBX1 -->|"interacts with"| Cancer
    DRUG_RESISTANCE["DRUG_RESISTANCE"]
    YBX1 -->|"activates"| DRUG_RESISTANCE
    RPL17["RPL17"]
    RPL17 -->|"interacts with"| YBX1
    SU056["SU056"]
    SU056 -->|"inhibits"| YBX1
    NSUN2["NSUN2"]
    NSUN2 -->|"therapeutic target"| YBX1
    LRP1 -->|"activates"| YBX1
    TCF3["TCF3"]
    TCF3 -->|"activates"| YBX1
    RRM1["RRM1"]
    RRM1 -->|"therapeutic target"| YBX1
    GAIN["GAIN"]
    GAIN -->|"activates"| YBX1
    GENES["GENES"]
    GENES -->|"activates"| YBX1
    DNA["DNA"]
    DNA -->|"activates"| YBX1
    G3BP1["G3BP1"]
    G3BP1 -->|"activates"| YBX1
    RECQL4["RECQL4"]
    RECQL4 -->|"activates"| YBX1
    ELAVL1["ELAVL1"]
    ELAVL1 -->|"interacts with"| YBX1
    style YBX1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (74)

Target	Relation	Type	Str
m5C-modified mRNAs	binds	compound	0.95
m5C	binds	compound	0.95
Bladder Cancer	drives	disease	0.90
mRNA Stability	regulates	process	0.90
Yap Mrna Stability	promotes	process	0.90
Yap Mrna	binds	biomarker	0.88
Urothelial Carcinoma of Bladder	contributes_to	disease	0.88
HDGF	upregulates	gene	0.85
Bladder Cancer	biomarker_for	disease	0.80
Cancer	activates	disease	0.75
Carcinoma	activates	disease	0.75
Tumor	activates	disease	0.75
LRP1	activates	protein	0.72
LRP1	regulates	protein	0.72
Als	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	expressed_in	disease	0.65
Ms	activates	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Tumor	regulates	disease	0.65
Cancer	associated_with	disease	0.65
Cancer	interacts_with	disease	0.65
Pancreatic Cancer	activates	disease	0.65
Als	inhibits	disease	0.65
DRUG_RESISTANCE	activates	phenotype	0.64
NSUN2	causes	gene	0.60
JUN	activates	gene	0.60
HERC5	regulates	gene	0.60
Nf-Κb	activates	pathway	0.60
CANCER	activates	gene	0.60
GENE MUTATIONS	activates	gene	0.60
ATP	activates	gene	0.60
Wnt	activates	pathway	0.60
ELAVL1	interacts_with	gene	0.60
TCF3	activates	gene	0.60
CAT	inhibits	gene	0.60
PEX1	inhibits	gene	0.60
SPP1	activates	gene	0.60
G3BP1	activates	gene	0.60
MECP2	therapeutic_target	gene	0.60
HSPA1A	therapeutic_target	gene	0.60
SYNCRIP	therapeutic_target	gene	0.60
G3BP1	therapeutic_target	gene	0.60
HSPA1A	activates	gene	0.60
Mtor	therapeutic_target	pathway	0.60
Ras	activates	protein	0.60
App	activates	protein	0.60
Drug Resistance	therapeutic_target	pathway	0.60
Multidrug Resistance	activates	pathway	0.60

Incoming (74)

Source	Relation	Type	Str
ALYREF	interacts_with	gene	0.85
RPL17	interacts_with	gene	0.80
SU056	inhibits	drug	0.72
GENES	activates	gene	0.70
AND	activates	gene	0.60
HDGF	biomarker_for	gene	0.60
ERK	inhibits	gene	0.60
JAK	inhibits	gene	0.60
JAK	activates	gene	0.60
RNA	interacts_with	gene	0.60
TCF3	activates	gene	0.60
PEX3	inhibits	gene	0.60
UBIQUITIN	regulates	gene	0.60
JAK2	inhibits	gene	0.60
JAK2	activates	gene	0.60
NSUN2	interacts_with	gene	0.60
AGO2	activates	gene	0.60
CTGF	activates	gene	0.60
MMP2	activates	gene	0.60
MMP9	activates	gene	0.60
NSUN2	activates	gene	0.60
HDGF	therapeutic_target	gene	0.60
DNA	activates	gene	0.60
RNA	activates	gene	0.60
CANCER	therapeutic_target	gene	0.60
YAP	interacts_with	gene	0.60
YAP	activates	gene	0.60
LRP1	activates	gene	0.60
IGF2BP1	therapeutic_target	gene	0.60
EWSR1	therapeutic_target	gene	0.60
JAK2	regulates	gene	0.60
CD44	therapeutic_target	gene	0.60
EGFR	activates	gene	0.60
ABCB1	activates	gene	0.60
BCL2	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
RNA	inhibits	gene	0.60
BECN1	targets	gene	0.60
CYP27B1	targets	gene	0.60
GCLC	targets	gene	0.60
PCBP2	targets	gene	0.60
PEX13	targets	gene	0.60
PPP1CA	targets	gene	0.60
VPS29	targets	gene	0.60
VPS35	targets	gene	0.60
ERBB2	activates	gene	0.60
AND	causes	gene	0.60
NSUN2	therapeutic_target	gene	0.60
NSUN2	causes	gene	0.60
PTEN	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning YBX1 in their description or question text

No additional research found