gene

KCNQ3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNQ3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

21Connections

0Hypotheses

0Analyses

13Outgoing

8Incoming

0Experiments

0Debates

Summary

KCNQ3 is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, implicated in. Associated with Als, Cancer, Ms. Connected to 20 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	KCNQ3
Full Name	Potassium Voltage-Gated Channel Subfamily Q Member 3
Chromosome	8q24.22
Protein Type	Channel
Function	M-channels are slowly activating and deactivating potassium channels that regulate neuronal excitability by controlling the resting membrane potential [@jentsch2000].
Primary Expression	Brain, Substantia Nigra, Cortex, Hippocampus
Molecular Weight	95.5 kDa
UniProt ID	O43525
NCBI Gene ID	3786
Ensembl ID	ENSG00000184160
OMIM	121201
GeneCards	KCNQ3
Human Protein Atlas	KCNQ3
Interactions	ANXIETY, CANCER, EGFR, ERK, RUNX1
KG Connections	21 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KCNQ3 — AlphaFold O43525 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    KCNQ3["KCNQ3"]
    Als{"Als"}
    KCNQ3 -->|"regulates"| Als
    Tumor{"Tumor"}
    KCNQ3 -->|"activates"| Tumor
    Ms{"Ms"}
    KCNQ3 -->|"regulates"| Ms
    Cancer{"Cancer"}
    KCNQ3 -->|"activates"| Cancer
    EGFR["EGFR"]
    KCNQ3 -->|"activates"| EGFR
    KCNQ2["KCNQ2"]
    KCNQ3 -->|"regulates"| KCNQ2
    MECP2["MECP2"]
    KCNQ3 -->|"regulates"| MECP2
    ERK["ERK"]
    KCNQ3 -->|"activates"| ERK
    GENES["GENES"]
    KCNQ3 -->|"regulates"| GENES
    RUNX1["RUNX1"]
    KCNQ3 -->|"activates"| RUNX1
    HDAC2["HDAC2"]
    KCNQ3 -->|"regulates"| HDAC2
    AND["AND"]
    KCNQ3 -->|"activates"| AND
    ERK -->|"activates"| KCNQ3
    HDAC2 -->|"regulates"| KCNQ3
    EGFR -->|"activates"| KCNQ3
    MECP2 -->|"regulates"| KCNQ3
    CANCER["CANCER"]
    CANCER -->|"activates"| KCNQ3
    KCNQ2 -->|"regulates"| KCNQ3
    GENES -->|"regulates"| KCNQ3
    RUNX1 -->|"activates"| KCNQ3
    style KCNQ3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (13)

Target	Relation	Type	Str
Als	regulates	disease	0.65
Tumor	activates	disease	0.65
Ms	regulates	disease	0.65
Cancer	activates	disease	0.65
ERK	activates	gene	0.60
EGFR	activates	gene	0.60
RUNX1	activates	gene	0.60
GENES	regulates	gene	0.60
KCNQ2	regulates	gene	0.60
MECP2	regulates	gene	0.60
HDAC2	regulates	gene	0.60
ANXIETY	activates	gene	0.60
Neuron	activates	cell_type	0.60

Incoming (8)

Source	Relation	Type	Str
GENES	regulates	gene	0.60
RUNX1	activates	gene	0.60
KCNQ2	regulates	gene	0.60
HDAC2	regulates	gene	0.60
EGFR	activates	gene	0.60
MECP2	regulates	gene	0.60
ERK	activates	gene	0.60
CANCER	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KCNQ3 in their description or question text

No additional research found