concept

RUNX1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RUNX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

84Connections

0Hypotheses

0Analyses

48Outgoing

36Incoming

0Experiments

0Debates

Summary

RUNX1 is a concept in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with Als, Alzheimer's disease, Cancer. Connected to 51 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	RUNX1
Key Genes/Proteins	AKT, ALS, AMPK, AND, ANG, APOE
Related Diseases	Als, Alzheimer's disease, Cancer
Related Pathways	Akt

Pathway Diagram

graph TD
    RUNX1["RUNX1"]
    RUNX1 -->|"regulates"| osteoblastogenesis["osteoblastogenesis"]
    RUNX1 -.biomarker for.-> Alzheimer_s_disease["Alzheimer's disease"]
    RUNX1 -->|"target for"| Leukemia["Leukemia"]
    RUNX1 -->|"target for"| Als["Als"]
    RUNX1 -->|"activates"| Tumor["Tumor"]
    RUNX1 -->|"regulates"| Ms["Ms"]
    RUNX1 -->|"activates"| Cancer["Cancer"]
    RUNX1 -->|"activates"| Cardiovascular["Cardiovascular"]
    RUNX1 -->|"activates"| HDAC2["HDAC2"]
    RUNX1 -->|"activates"| Tgf__["Tgf-Beta"]
    BCL_2["BCL-2"] -->|"target for"| RUNX1
    ETV6["ETV6"] -->|"activates"| RUNX1
    KMT2A["KMT2A"] -->|"target for"| RUNX1
    KCNQ3["KCNQ3"] -->|"activates"| RUNX1
    EGFR["EGFR"] -->|"activates"| RUNX1
    KCNQ2["KCNQ2"] -->|"activates"| RUNX1
    MECP2["MECP2"] -->|"regulates"| RUNX1
    ERK["ERK"] -->|"activates"| RUNX1
    GENES["GENES"] -->|"activates"| RUNX1
    ANG["ANG"] -->|"activates"| RUNX1
    NRP1["NRP1"] -->|"activates"| RUNX1
    APOE["APOE"] -->|"activates"| RUNX1

Outgoing (48)

Target	Relation	Type	Str
Cancer Cachexia	associated_with	disease	0.85
osteoblastogenesis	regulates	pathway	0.80
Alzheimer's disease	biomarker_for	disease	0.70
Cancer	therapeutic_target	disease	0.65
Glioblastoma	activates	disease	0.65
Cardiovascular	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Als	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Leukemia	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Tumor	activates	disease	0.65
Ms	regulates	disease	0.65
Cancer	activates	disease	0.65
Cardiovascular	activates	disease	0.65
TAU	inhibits	gene	0.60
Akt	inhibits	pathway	0.60
GLIOBLASTOMA	activates	gene	0.60
ALS	inhibits	gene	0.60
Tgf-Β	activates	pathway	0.60
HDAC2	activates	gene	0.60
Wnt	inhibits	pathway	0.60
G3BP1	inhibits	gene	0.60
ATM	inhibits	gene	0.60
P53	inhibits	gene	0.60
YAP1	activates	gene	0.60
AMPK	inhibits	gene	0.60
WNT	inhibits	gene	0.60
CANCER	activates	gene	0.60
PTEN	inhibits	gene	0.60
HDAC7	activates	gene	0.60
NEURODEGENERATIVE DISEASES	inhibits	gene	0.60
AKT	inhibits	gene	0.60
UBIQUITIN	inhibits	gene	0.60
Hedgehog	regulates	pathway	0.60
STAT3	regulates	gene	0.60
Notch	regulates	pathway	0.60
Wnt	regulates	pathway	0.60
Tgf-Β	regulates	pathway	0.60
Epigenetic	regulates	pathway	0.60
AND	activates	gene	0.60
ST3GAL2	activates	gene	0.60
ST8SIA1	activates	gene	0.60
EGFR	activates	gene	0.60
KCNQ3	activates	gene	0.60
MECP2	regulates	gene	0.60
microglia	expressed_in	cell_type	0.55

Incoming (36)

Source	Relation	Type	Str
DAP12	regulates	gene	0.60
GATA1	activates	gene	0.60
GATA2	activates	gene	0.60
ANG	activates	gene	0.60
NRP1	activates	gene	0.60
APOE	activates	gene	0.60
SLC44A2	associated_with	gene	0.60
HDAC2	activates	gene	0.60
NPM1	associated_with	gene	0.60
PER	therapeutic_target	gene	0.60
TP53	associated_with	gene	0.60
TET2	associated_with	gene	0.60
DNMT3A	associated_with	gene	0.60
NRAS	associated_with	gene	0.60
CANCER	therapeutic_target	gene	0.60
IDH1	associated_with	gene	0.60
IDH2	associated_with	gene	0.60
AXIN1	inhibits	gene	0.60
KCNQ3	activates	gene	0.60
EGFR	activates	gene	0.60
KCNQ2	activates	gene	0.60
MECP2	regulates	gene	0.60
ERK	activates	gene	0.60
GENES	activates	gene	0.60
CANCER	activates	gene	0.60
HIPPO	regulates	gene	0.60
TAZ	associated_with	gene	0.60
RUNX2	associated_with	gene	0.60
SATB2	associated_with	gene	0.60
PIEZO1	regulates	gene	0.60
ATF4	associated_with	gene	0.60
YAP	associated_with	gene	0.60
RNA	regulates	gene	0.60
BCL-2	therapeutic_target	gene	0.60
ETV6	activates	gene	0.60
KMT2A	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RUNX1 in their description or question text

No additional research found