protein

MECP2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MECP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

241Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

Methyl-CpG Binding Protein 2 (MECP2) is a transcriptional regulator critical for neuronal development and function. MECP2 mutations cause Rett syndrome and are implicated in MECP2 duplication syndrome and other neuropsychiatric disorders.

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🔬 Protein Info

Gene Symbol	MECP2
Full Name	Methyl-CpG Binding Protein 2
Protein Family	Methyl-CpG binding domain (MBD) family
Function	In neurons, MeCP2 binds broadly across the genome, preferentially at methylated CpG dinucleotides and non-CpG methylation sites (particularly mCA), which are highly abundant in mature neurons [@birdse
Primary Expression	Cerebral cortex, Hippocampus, Cerebellum, Brainstem, Basal ganglia, Thalamus
Subcellular Localization	Nucleus (chromatin-associated)
Molecular Weight	53 kDa
Amino Acids	80 aa
Pathways	Akt, Epigenetic, Mapk, Mitophagy
UniProt ID	P51608
Ensembl ID	ENSG00000169057
GeneCards	MECP2
Human Protein Atlas	MECP2
Associated Diseases	Als, Autism, epilepsy, Rett syndrome
Interactions	Actin, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-BETA, AND
KG Connections	235 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: MECP2 — AlphaFold P51608 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

MECP2 — Methyl-CpG Binding Protein 2

gene · 1655 words

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MECP2 Protein

protein · 940 words

→

Pathway Diagram

graph TD
    MECP2["MECP2"] -->|"regulates"| MMP9["MMP9"]
    MECP2["MECP2"] -->|"interacts"| SIRT1["SIRT1"]
    MECP2["MECP2"] -->|"causes"| Rett_syndrome["Rett syndrome"]
    MECP2["MECP2"] -->|"regulates"| BDNF["BDNF"]
    MECP2["MECP2"] -.->|"inhibits"| Ms["Ms"]
    MECP2["MECP2"] -.->|"inhibits"| Depression["Depression"]
    FUS["FUS"] -->|"regulates"| MECP2["MECP2"]
    NRBP1["NRBP1"] -.->|"inhibits"| MECP2["MECP2"]
    BDNF_1["BDNF"] -->|"activates"| MECP2["MECP2"]
    CSF1R["CSF1R"] -.->|"inhibits"| MECP2["MECP2"]
    style MECP2 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (159)

Target	Relation	Type	Str
APOPTOSIS	represses	process	0.80
SYP	co_expressed_with	protein	0.75
5hmC binding	targets	mechanism	0.70
MMP9	regulates	protein	0.70
Rett syndrome	causes	disease	0.70
Neuronal dysfunction	causes	phenotype	0.70
BDNF	regulates	protein	0.70
SIRT1	interacts_with	protein	0.70
Als	expressed_in	disease	0.65
Als	associated_with	disease	0.65
Ms	expressed_in	disease	0.65
Autism	associated_with	disease	0.65
Als	inhibits	disease	0.65
Cancer	therapeutic_target	disease	0.65
ALS	activates	disease	0.65
Ischemia	activates	disease	0.65
Stroke	regulates	disease	0.65
Depression	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Als	regulates	disease	0.65
Tumor	regulates	disease	0.65
Alzheimer	activates	disease	0.65
Ms	regulates	disease	0.65
Cancer	regulates	disease	0.65
Epilepsy	causes	disease	0.65
Ms	activates	disease	0.65
Depression	activates	disease	0.65
Als	activates	disease	0.65
Aging	regulates	disease	0.65
Epilepsy	encodes	disease	0.65
ALS	expressed_in	disease	0.65
Epilepsy	therapeutic_target	disease	0.65
Aging	activates	disease	0.65
Ngf	associated_with	protein	0.60
APOPTOSIS	activates	gene	0.60
Apoptosis	activates	pathway	0.60
Akt	regulates	pathway	0.60
Mapk	regulates	pathway	0.60
NEURON	inhibits	gene	0.60
MICROGLIA	activates	gene	0.60
EPILEPSY	therapeutic_target	gene	0.60
Epigenetic	associated_with	pathway	0.60
Neuron	associated_with	cell_type	0.60
GENES	inhibits	gene	0.60
Huntingtin	regulates	protein	0.60
EPILEPSY	encodes	gene	0.60
Epigenetic	encodes	pathway	0.60
Insulin	therapeutic_target	protein	0.60
C-JUN	activates	gene	0.60
AND	inhibits	gene	0.60

Incoming (82)

Source	Relation	Type	Str
20188665	binds in association with	paper	0.90
20188665	recruits	paper	0.90
FUS	regulates	protein	0.80
CREB	interacts_with	protein	0.70
ERK	regulates	gene	0.60
ERK	activates	gene	0.60
FLAVONOIDS	therapeutic_target	gene	0.60
NATURAL COMPOUNDS	therapeutic_target	gene	0.60
MITOPHAGY	regulates	gene	0.60
EPILEPSY	causes	gene	0.60
POLE	therapeutic_target	gene	0.60
HTT	activates	gene	0.60
HUNTINGTIN	regulates	gene	0.60
CALCINEURIN	activates	gene	0.60
POLE	encodes	gene	0.60
KCNQ2	regulates	gene	0.60
NRBP1	inhibits	gene	0.60
BDNF	activates	gene	0.60
CSF1R	inhibits	gene	0.60
KCNQ3	regulates	gene	0.60
EGFR	regulates	gene	0.60
IGF2BP1	therapeutic_target	gene	0.60
EWSR1	therapeutic_target	gene	0.60
YBX1	therapeutic_target	gene	0.60
IL6	regulates	gene	0.60
FAS	activates	gene	0.60
MAPK1	regulates	gene	0.60
IL1B	regulates	gene	0.60
MYC	regulates	gene	0.60
AKT	regulates	gene	0.60
MICROGLIA	activates	gene	0.60
ASTROCYTE	inhibits	gene	0.60
CREB	activates	gene	0.60
GENES	regulates	gene	0.60
CANCER	regulates	gene	0.60
RUNX1	regulates	gene	0.60
20188665	dampens	paper	0.60
MICROGLIA	inhibits	gene	0.60
MIR-155	therapeutic_target	gene	0.60
HDAC2	regulates	gene	0.60
NEURON	inhibits	gene	0.60
BNIP3L	expressed_in	gene	0.60
ERK	inhibits	gene	0.60
DNMT3A	regulates	gene	0.60
BRAIN INJURY	regulates	gene	0.60
STROKE	regulates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
DNA	inhibits	gene	0.60
DEPRESSION	inhibits	gene	0.60
RNA	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Are age-related static epigenetic patterns pathogenic or protective compensatory

epigenetics | 2026-04-15 | 0 hypotheses

Epigenetic clocks and biological aging in neurodegeneration

neurodegeneration | 2026-04-01 | 6 hypotheses Top: 0.710

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

The debate assumed static 5-hydroxymethylcytosine patterns in aging neurons are

closed · Rounds: 4 · Score: 0.95 · 2026-04-16

Epigenetic clocks and biological aging in neurodegeneration

closed · Rounds: 4 · Score: 0.93 · 2026-04-06

Related Research

Hypotheses and analyses mentioning MECP2 in their description or question text

No additional research found