concept

IGF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IGF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

249Connections

7Hypotheses

1Analyses

50Outgoing

50Incoming

1Experiments

1Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	IGF
Linked Hypotheses	9 hypotheses

Wiki Pages (14)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    IGF["IGF"]
    style IGF fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    IGF -->|"target for"| Als["Als"]
    IGF -->|"regulates"| Fibrosis["Fibrosis"]
    IGF -->|"target for"| Aging["Aging"]
    IGF -->|"target for"| Neurodegeneration["Neurodegeneration"]
    IGF -->|"target for"| Cancer["Cancer"]
    IGF -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    ROS([ROS]) -->|"regulates"| IGF
    HSPG2([HSPG2]) -->|"regulates"| IGF
    RNA([RNA]) -->|"regulates"| IGF
    DAG1([DAG1]) -->|"regulates"| IGF
    BAD([BAD]) -->|"regulates"| IGF
    IGF1R([IGF1R]) -->|"regulates"| IGF
    YTHDF1([YTHDF1]) -->|"target for"| IGF
    IGF2BP1([IGF2BP1]) -->|"target for"| IGF
    TDP_43([TDP-43]) -->|"target for"| IGF
    ELAVL2([ELAVL2]) -->|"target for"| IGF

Outgoing (62)

Target	Relation	Type	Str
Als	therapeutic_target	disease	0.60
Fibrosis	regulates	disease	0.60
Aging	therapeutic_target	disease	0.60
Neurodegeneration	therapeutic_target	disease	0.60
Senescence	biomarker_for	disease	0.60
Aging	biomarker_for	disease	0.60
Fibrosis	biomarker_for	disease	0.60
Fibrosis	activates	disease	0.60
Anxiety	regulates	disease	0.60
Alzheimer	regulates	disease	0.60
Aging	associated_with	disease	0.60
Atherosclerosis	associated_with	disease	0.60
Senescence	activates	disease	0.60
Depression	activates	disease	0.60
Neurodegeneration	activates	disease	0.60
Cancer	activates	disease	0.60
Senescence	associated_with	disease	0.60
Diabetes	activates	disease	0.60
Glioblastoma	expressed_in	disease	0.60
Cancer	expressed_in	disease	0.60
Neuroinflammation	expressed_in	disease	0.60
Alzheimer	expressed_in	disease	0.60
Alzheimer	therapeutic_target	disease	0.60
Aging	regulates	disease	0.60
Als	associated_with	disease	0.60
Als	interacts_with	disease	0.60
Cancer	associated_with	disease	0.60
Als	causes	disease	0.60
Als	activates	disease	0.60
Aging	activates	disease	0.60
Amyotrophic Lateral Sclerosis	associated_with	disease	0.60
Parkinson	associated_with	disease	0.60
Huntington	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
Cancer	therapeutic_target	disease	0.60
Diabetes	associated_with	disease	0.60
Neuroinflammation	regulates	disease	0.60
Neurodegeneration	associated_with	disease	0.60
Alzheimer	activates	disease	0.60
Als	inhibits	disease	0.60
Atherosclerosis	therapeutic_target	disease	0.60
Mapk	therapeutic_target	pathway	0.55
Autophagy	therapeutic_target	pathway	0.55
Wnt	therapeutic_target	pathway	0.55
Mtor	therapeutic_target	pathway	0.55
Blood-Brain Barrier	regulates	pathway	0.55
Notch	associated_with	pathway	0.55
Innate Immunity	therapeutic_target	pathway	0.55
Neurogenesis	activates	pathway	0.55
Wnt	associated_with	pathway	0.55

Incoming (187)

Source	Relation	Type	Str
RNA	activates	gene	0.60
EGFR	activates	gene	0.60
SENP1	activates	gene	0.60
IGF2BP3	activates	gene	0.60
AKT	activates	gene	0.60
HDAC2	activates	gene	0.60
ROS	associated_with	gene	0.60
MTOR	regulates	gene	0.60
NRF2	regulates	gene	0.60
IGF-1	regulates	gene	0.60
OVERVIEW	therapeutic_target	gene	0.60
AMPK	activates	gene	0.60
MITOPHAGY	therapeutic_target	gene	0.60
EXERCISE	therapeutic_target	gene	0.60
CATHEPSIN-B	activates	gene	0.60
FGF21	activates	gene	0.60
GSK3B	therapeutic_target	gene	0.60
CACNA1C	therapeutic_target	gene	0.60
MMP9	therapeutic_target	gene	0.60
INS	therapeutic_target	gene	0.60
IGF1R	therapeutic_target	gene	0.60
GSK3	therapeutic_target	gene	0.60
TGFB1	therapeutic_target	gene	0.60
ESR1	therapeutic_target	gene	0.60
TAU	therapeutic_target	gene	0.60
APP	therapeutic_target	gene	0.60
CDK5	therapeutic_target	gene	0.60
MAPT	therapeutic_target	gene	0.60
MMP2	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
ROS	regulates	gene	0.60
HSPG2	regulates	gene	0.60
RNA	regulates	gene	0.60
DAG1	regulates	gene	0.60
BAD	regulates	gene	0.60
IGF1R	regulates	gene	0.60
SYNE2	associated_with	gene	0.60
SMARCB1	associated_with	gene	0.60
SFPQ	associated_with	gene	0.60
SYNCRIP	associated_with	gene	0.60
COPA	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
IGF2R	associated_with	gene	0.60
APP	associated_with	gene	0.60
RNF14	associated_with	gene	0.60
APOE	associated_with	gene	0.60
STXBP3	associated_with	gene	0.60
SSBP1	associated_with	gene	0.60
CALB1	associated_with	gene	0.60
IDS	associated_with	gene	0.60

Targeting Hypotheses (7)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
AAV-PHP.eB-Mediated Microglial IGFBPL1 Expression	0.720	drug delivery	Can IGFBPL1 therapeutics effectively cro
IGFBPL1-Mediated Homeostatic Restoration	0.584	Alzheimer's disease	Neuroinflammation and microglial priming
IGFBPL1-Mediated Microglial Reprogramming	0.579	neurodegeneration	Neuroinflammation and microglial priming
Fusing IGFBPL1 to IGF-1 for Receptor-Mediated BBB Transcytos	0.550	drug delivery	Can IGFBPL1 therapeutics effectively cro
Lipid Nanoparticle Encapsulation of IGFBPL1-mRNA	0.520	drug delivery	Can IGFBPL1 therapeutics effectively cro

Intranasal IGFBPL1 Delivery via Olfactory Pathway	0.470	drug delivery	Can IGFBPL1 therapeutics effectively cro
IGFBPL1 Peptide Mimetics for Drug-Like BBB Permeability	0.420	drug delivery	Can IGFBPL1 therapeutics effectively cro

Mentioning Analyses (1)

Scientific analyses that reference this entity

Can IGFBPL1 therapeutics effectively cross the blood-brain barrier to reach CNS

drug delivery | 2026-04-06 | 7 hypotheses Top: 0.720

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
bEV-mediated synaptic pruning via C1q-C3 pathway	exploratory	Alzheimer's disease	0.850	0.00	microglia and synapses (in viv	proposed	N/A

Related Papers (9)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Insulin-Like Growth Factor Signaling in Alzheimer's Disease: Pathophysiology and [PMID:39240280]	Miao J, Zhang Y, Su C, Zheng Q, Guo J	Molecular neurobiology	2025	1
IGF2BP1 exacerbates neuroinflammation and cerebral ischemia/reperfusion injury b [PMID:40294852]	Li Y, Jiang J, Zhuo Y, Li J, Li Y, Xia Y	Biochimica et biophysica acta.	2025	1
Functional assessments through novel proteomics approaches: Application to insul [PMID:30412730]	Ayyadevara S, Ganne A, Hendrix RD, Balas	Journal of neuroscience method	2019	1
Neuronal functions of FOXO/DAF-16. [PMID:28447066]	Kim SY, Webb AE	Nutrition and healthy aging	2017	1
Caloric restriction. [PMID:21840335]	Speakman JR, Mitchell SE	Molecular aspects of medicine	2011	1
Microglia-mediated IGF-I neuroprotection in the rd10 mouse model of retinitis pi [PMID:22039242]	Arroba AI, Alvarez-Lindo N, van Rooijen	Investigative ophthalmology &	2011	1
Semaglutide treatment reverses HFD induced hippocampal microglia activation and [PMID:41916100]	["Gong Haodong", "Liu Junlu", "Wang Yiha	Tissue & cell	2026	0
α-Synuclein oligomers potentiate neuroinflammatory NF-κB activity and induce Ca [PMID:38378800]	["Leandrou Emmanouela", "Chalatsa Ioanna	Translational neurodegeneratio	2024	0
IGFBPL1 is a master driver of microglia homeostasis and resolution of neuroinfla [PMID:37527036]	Pan L, Cho KS, Wei X, Xu F, Lennikov A,	Cell reports	2023	0

Debates (1)

Multi-agent debates referencing this entity

The debate highlighted IGFBPL1's potential as a microglial master regulator but

closed · Rounds: 4 · Score: 0.69 · 2026-04-22

Related Research

Hypotheses and analyses mentioning IGF in their description or question text

Intranasal IGFBPL1 Delivery via Olfactory Pathway

Score: 0.470 · drug delivery · 2026-04-22

## Mechanistic Overview Intranasal IGFBPL1 Delivery via Olfactory Pathway starts from the claim that modulating IGFBPL1

IGFBPL1 Peptide Mimetics for Drug-Like BBB Permeability

Score: 0.420 · drug delivery · 2026-04-22

## Mechanistic Overview IGFBPL1 Peptide Mimetics for Drug-Like BBB Permeability starts from the claim that modulating IG

IGF

Understanding Entity Pages

Wiki Pages (14)

Expanded to 3000+ words

IGF-1 Signaling Pathway in Neurodegeneration

IGF2 Protein (Insulin-like Growth Factor 2)

Insulin and IGF Signaling in 4R-Tauopathies

IGF2BP3 — Insulin-Like Growth Factor 2 mRNA-Binding Protein 3

IGF2BP2

IGF2BP1

IGF2BP1 Protein

IGF2R Protein

IGF1 Gene

IGF2 (Insulin-Like Growth Factor 2)

IGF2BP2 Protein

IGF1R Gene

IGF-1 Receptor Neurons