gene 1,597 words KG: IGF2BP1
Contents

IGF2BP1

🧬 Gene Info
Gene SymbolIGF2BP1
Full NameInsulin-Like Growth Factor 2 mRNA-Binding Protein 1
AliasesIMP1/CRD-BP
Chromosome17q21.32
Functionis a member of the IMP family of RNA-binding proteins.
Molecular Weight75 kDa
Amino Acids660 aa
Exons17
PathwaysLarval Brain Development, Neural Fate Specification, Neural Progenitor Patterning
UniProt IDQ9Y296
NCBI Gene ID10682
Ensembl IDENSG00000159248
OMIM608288
GeneCardsIGF2BP1
Human Protein AtlasIGF2BP1
Associated DiseasesAging, Als, Cancer, Ftd, Neurodegeneration
Known Drugs/CompoundsN6-Methyladenosine
InteractionsAND, ANK2, COMPLEMENT, ELAVL2, FUS, G3BP1
KG Connections249 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (15)

SASP-Mediated Complement Cascade Amplification
Score: 0.91
APOE-Dependent Autophagy Restoration
Score: 0.85
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Phase-Separated Organelle Targeting
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (7)

Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: co_discussed
Gene Page: ANK2 (Ankyrin-2)
gene · KG edge: interacts_with
BDNF Gene
gene · KG edge: associated_with
C1QA Gene — Complement Component 1q A Chain
gene · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with

Knowledge Graph (12 edges)

ELAVL2 therapeutic_target IGF2BP1
C1Q therapeutic_target IGF2BP1
MTOR therapeutic_target IGF2BP1
CLPP therapeutic_target IGF2BP1
RAB11 therapeutic_target IGF2BP1
STX17 therapeutic_target IGF2BP1
RAB5 therapeutic_target IGF2BP1
SNAP29 therapeutic_target IGF2BP1
IGF2BP1 therapeutic_target LONP1
IGF2BP1 therapeutic_target BDNF

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