gene

ELAVL2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ELAVL2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

186Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ELAVL2 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, associated with, activates. Associated with ALS, Aging, Als. Connected to 101 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ELAVL2
Full Name	ELAV Like RNA Binding Protein 2
Chromosome	9p21.3
Protein Family	ELAVL (Embryonic Lethal, Abnormal Vision, Drosophila-like)
Function	ELAVL2 is a member of the ELAVL family (ELAVL1-4) that is expressed specifically in neurons and primarily localizes to the cytoplasm.
Subcellular Localization	of specific mRNAs within neurons, enabling localized protein synthesis at synapses
Molecular Weight	39 kDa
Pathways	Cholesterol, Lipid Metabolism, Neurogenesis, Translation Fidelity
GeneCards	ELAVL2
Human Protein Atlas	ELAVL2
Associated Diseases	Aging, Als, Ftd, Neurodegeneration
Interactions	BRAIN INJURY, FN1, FUS, GFAP, IGF2BP1, METTL3
KG Connections	186 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ELAVL2 Gene

gene · 924 words

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Pathway Diagram

graph TD
    ELAVL2["ELAVL2"]
    ELAVL2 -->|"target for"| Neurodegeneration["Neurodegeneration"]
    ELAVL2 -->|"target for"| Aging["Aging"]
    ELAVL2 -->|"target for"| Ms["Ms"]
    ELAVL2 -->|"target for"| Als["Als"]
    ELAVL2 -->|"activates"| Traumatic_Brain_Injury["Traumatic Brain Injury"]
    ELAVL2 -->|"target for"| C1Q["C1Q"]
    ELAVL2 -->|"target for"| MTOR["MTOR"]
    ELAVL2 -->|"target for"| CLPP["CLPP"]
    ELAVL2 -->|"target for"| RAB11["RAB11"]
    PI3K["PI3K"] -->|"target for"| ELAVL2
    C1Q -->|"target for"| ELAVL2
    AUTOPHAGY["AUTOPHAGY"] -->|"target for"| ELAVL2
    SNAP29["SNAP29"] -->|"target for"| ELAVL2
    MTOR -->|"target for"| ELAVL2
    IGF2BP1["IGF2BP1"] -->|"target for"| ELAVL2
    FUS["FUS"] -->|"target for"| ELAVL2
    AKT["AKT"] -->|"target for"| ELAVL2
    LONP1["LONP1"] -->|"target for"| ELAVL2
    BDNF["BDNF"] -->|"target for"| ELAVL2

Outgoing (127)

Target	Relation	Type	Str
Translation Fidelity	regulates	process	0.85
ALS	associated_with	disease	0.65
Ms	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Neurodegeneration	encodes	disease	0.65
Aging	associated_with	disease	0.65
Als	encodes	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Ftd	associated_with	disease	0.65
Ftd	therapeutic_target	disease	0.65
Aging	encodes	disease	0.65
Als	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Wnt	therapeutic_target	pathway	0.60
Mapk	therapeutic_target	pathway	0.60
METTL3	therapeutic_target	gene	0.60
BDNF	therapeutic_target	gene	0.60
Sumo	therapeutic_target	protein	0.60
LONP1	therapeutic_target	gene	0.60
Mtor	therapeutic_target	pathway	0.60
CLPP	therapeutic_target	gene	0.60
Autophagy	therapeutic_target	pathway	0.60
Pi3K	therapeutic_target	pathway	0.60
FUS	therapeutic_target	gene	0.60
RAB11	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
Complement	therapeutic_target	pathway	0.60
C1Q/C3	therapeutic_target	gene	0.60
IGF2BP1	regulates	entity	0.60
IGF2BP1	therapeutic_target	gene	0.60
FUS	regulates	entity	0.60
CLPP	associated_with	gene	0.60
SNAP29	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
SNAP29	encodes	gene	0.60
FUS	encodes	gene	0.60
TDP-43	encodes	gene	0.60
STX17	encodes	gene	0.60
RAB5	encodes	gene	0.60
CLPP	encodes	gene	0.60
BDNF	encodes	gene	0.60
IGF2BP1	encodes	gene	0.60
RAB11	encodes	gene	0.60
C1Q	associated_with	gene	0.60
Rb	therapeutic_target	protein	0.60
FUS	interacts_with	gene	0.60
RAB5	therapeutic_target	gene	0.60

Incoming (59)

Source	Relation	Type	Str
C1Q	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
LONP1	associated_with	gene	0.60
CLPP	associated_with	gene	0.60
CLPP	therapeutic_target	gene	0.60
FN1	activates	gene	0.60
YTHDF1	therapeutic_target	gene	0.60
YTHDF1	associated_with	gene	0.60
RAB5	therapeutic_target	gene	0.60
STX17	therapeutic_target	gene	0.60
WNT	associated_with	gene	0.60
MAPK	associated_with	gene	0.60
RNA	associated_with	gene	0.60
AND	associated_with	gene	0.60
AKT	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
BDNF	therapeutic_target	gene	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
ALS	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
C1Q	therapeutic_target	gene	0.60
SNAP29	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
IGF2BP1	therapeutic_target	gene	0.60
FUS	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
LONP1	therapeutic_target	gene	0.60
CD44	associated_with	gene	0.60
GFAP	activates	gene	0.60
LGALS3	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
FUS	associated_with	gene	0.60
RAB5	associated_with	gene	0.60
C1Q/C3	associated_with	gene	0.60
RAB11	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
STX17	associated_with	gene	0.60
IGF2BP1	associated_with	gene	0.60
TDP-43	therapeutic_target	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
METTL3	associated_with	gene	0.60
METTL3	therapeutic_target	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.60
LYSOSOME	therapeutic_target	gene	0.60
COMPLEMENT	therapeutic_target	gene	0.60
AND	therapeutic_target	gene	0.60
AGING	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
ALS	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ELAVL2 in their description or question text

No additional research found