gene

IGF2BP3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IGF2BP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

40Connections

0Hypotheses

0Analyses

24Outgoing

16Incoming

0Experiments

0Debates

Summary

IGF2BP3 is a gene implicated in neurodegeneration research. Key relationships include: regulates, therapeutic target, implicated in. Associated with Cancer, Ovarian Cancer. Connected to 13 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	IGF2BP3
Full Name	Insulin-Like Growth Factor 2 mRNA-Binding Protein 3
Chromosome	7p11
Protein Type	Gene
Function	is a member of the VICKZ family of RNA-binding proteins.
Molecular Weight	64 kDa
Amino Acids	579 aa
Exons	17
Pathways	Autophagy
GeneCards	IGF2BP3
Human Protein Atlas	IGF2BP3
KH domains 1-4 (N-terminal)	Primary RNA-binding domains recognizing a consensus motif (ACACGCC)
KH domains 5-6 (C-terminal)	Contribute to RNA binding and protein-protein interactions
QRMs 1-4	Located between KH domains
N-terminal region	Contains nuclear localization signals and export sequences
Associated Diseases	neurodegeneration
Interactions	AKT, AND, APOPTOSIS, Egfr, EGFR, HDAC2
KG Connections	40 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

IGF2BP3 — Insulin-Like Growth Factor 2 mRNA-Binding Protein 3

gene · 2611 words

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Pathway Diagram

graph TD
    IGF2BP3["IGF2BP3"]
    ESM1(["ESM1"])
    IGF2BP3 -->|"regulates"| ESM1
    Ovarian_Cancer{"Ovarian Cancer"}
    IGF2BP3 -->|"therapeutic_target"| Ovarian_Cancer
    Cancer{"Cancer"}
    IGF2BP3 -->|"therapeutic_target"| Cancer
    Autophagy["Autophagy"]
    IGF2BP3 -->|"regulates"| Autophagy
    Cholesterol["Cholesterol"]
    IGF2BP3 -->|"associated_with"| Cholesterol
    Lipid_Metabolism["Lipid Metabolism"]
    IGF2BP3 -->|"therapeutic_target"| Lipid_Metabolism
    BECN1(["BECN1"])
    BECN1 -->|"therapeutic_target"| IGF2BP3
    HMGCR(["HMGCR"])
    HMGCR -->|"regulates"| IGF2BP3
    CANCER(["CANCER"])
    CANCER -->|"therapeutic_target"| IGF2BP3
    GENES(["GENES"])
    GENES -->|"regulates"| IGF2BP3
    style IGF2BP3 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (24)

Target	Relation	Type	Str
ESM1	regulates	protein	0.90
Ovarian Cancer	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
Leukemia	activates	disease	0.65
APOPTOSIS	activates	gene	0.60
RNA	activates	gene	0.60
lipid metabolism	participates_in	pathway	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
AND	activates	gene	0.60
Mtor	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
AKT	activates	gene	0.60
EGFR	activates	gene	0.60
MTOR	activates	gene	0.60
HDAC2	activates	gene	0.60
SENP1	activates	gene	0.60
Autophagy	regulates	pathway	0.60
Cholesterol	associated_with	pathway	0.60
Lipid Metabolism	therapeutic_target	pathway	0.60
Sumo	activates	protein	0.60
Egfr	activates	protein	0.60
Igf	activates	protein	0.60
Ras	activates	protein	0.60

Incoming (16)

Source	Relation	Type	Str
RNA	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
HDAC2	activates	gene	0.60
SENP1	activates	gene	0.60
ESM1	regulates	gene	0.60
BECN1	regulates	gene	0.60
BECN1	therapeutic_target	gene	0.60
HMGCR	regulates	gene	0.60
HSPA5	regulates	gene	0.60
RANK	regulates	gene	0.60
MTOR	activates	gene	0.60
EGFR	activates	gene	0.60
AKT	activates	gene	0.60
CANCER	therapeutic_target	gene	0.60
GENES	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IGF2BP3 in their description or question text

No additional research found