concept

INTERLEUKIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INTERLEUKIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

663Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	INTERLEUKIN

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Interleukin-6 (IL-6)

entity · 957 words

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Pathway Diagram

graph TD
    INTERLEUKIN["INTERLEUKIN"]
    style INTERLEUKIN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    INTERLEUKIN -->|"regulates"| Fibrosis["Fibrosis"]
    INTERLEUKIN -->|"target for"| Als["Als"]
    INTERLEUKIN -->|"interacts"| Cancer["Cancer"]
    INTERLEUKIN -->|"target for"| Multiple_Sclerosis["Multiple Sclerosis"]
    INTERLEUKIN -->|"target for"| Neuroinflammation["Neuroinflammation"]
    REL([REL]) -->|"regulates"| INTERLEUKIN
    IL_10([IL-10]) -->|"activates"| INTERLEUKIN
    CERS2([CERS2]) -->|"regulates"| INTERLEUKIN
    IGF1R([IGF1R]) -->|"regulates"| INTERLEUKIN
    DAG1([DAG1]) -->|"regulates"| INTERLEUKIN
    RNA([RNA]) -->|"regulates"| INTERLEUKIN
    ROS([ROS]) -->|"regulates"| INTERLEUKIN
    HSPG2([HSPG2]) -->|"regulates"| INTERLEUKIN
    RIPK1([RIPK1]) -->|"interacts"| INTERLEUKIN
    PPARG([PPARG]) -->|"interacts"| INTERLEUKIN

Outgoing (189)

Target	Relation	Type	Str
Fibrosis	interacts_with	disease	0.60
Cancer	interacts_with	disease	0.60
Aging	therapeutic_target	disease	0.60
Neuropathy	expressed_in	disease	0.60
Ferroptosis	activates	disease	0.60
Encephalitis	causes	disease	0.60
Meningitis	causes	disease	0.60
Encephalitis	inhibits	disease	0.60
Meningitis	inhibits	disease	0.60
Dementia	expressed_in	disease	0.60
Neurodegeneration	expressed_in	disease	0.60
Stroke	expressed_in	disease	0.60
Pyroptosis	causes	disease	0.60
Diabetes	activates	disease	0.60
Alzheimer	associated_with	disease	0.60
Atherosclerosis	associated_with	disease	0.60
Hypertension	associated_with	disease	0.60
Als	expressed_in	disease	0.60
Leukemia	inhibits	disease	0.60
Senescence	associated_with	disease	0.60
Aging	protects_against	disease	0.60
Senescence	protects_against	disease	0.60
Cancer	expressed_in	disease	0.60
Aging	activates	disease	0.60
Neurodegeneration	regulates	disease	0.60
Obesity	activates	disease	0.60
Depression	therapeutic_target	disease	0.60
Epilepsy	therapeutic_target	disease	0.60
Huntington	activates	disease	0.60
Als	activates	disease	0.60
Aging	associated_with	disease	0.60
Als	regulates	disease	0.60
Als	interacts_with	disease	0.60
Alzheimer	therapeutic_target	disease	0.60
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.60
Encephalitis	therapeutic_target	disease	0.60
Alzheimer	activates	disease	0.60
Stroke	therapeutic_target	disease	0.60
Leukemia	therapeutic_target	disease	0.60
Cancer	associated_with	disease	0.60
Stroke	biomarker_for	disease	0.60
Als	biomarker_for	disease	0.60
Atherosclerosis	biomarker_for	disease	0.60
Neuroinflammation	biomarker_for	disease	0.60
Alzheimer	expressed_in	disease	0.60
Atherosclerosis	expressed_in	disease	0.60
Pyroptosis	biomarker_for	disease	0.60
Necroptosis	biomarker_for	disease	0.60
Ferroptosis	biomarker_for	disease	0.60
Aging	expressed_in	disease	0.60

Incoming (474)

Source	Relation	Type	Str
PPARG	interacts_with	gene	0.60
WNT	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
CFTR	interacts_with	gene	0.60
RICTOR	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
HSP70	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
IFN	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
MLST8	interacts_with	gene	0.60
PARP1	inhibits	gene	0.60
EGR2	activates	gene	0.60
SIRT6	inhibits	gene	0.60
NAD	inhibits	gene	0.60
CD38	activates	gene	0.60
NAMPT	inhibits	gene	0.60
DNAJB9	associated_with	gene	0.60
AGING	associated_with	gene	0.60
HSPA1A	associated_with	gene	0.60
IL-17	activates	gene	0.60
MMP9	activates	gene	0.60
BAX	activates	gene	0.60
S100A8	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
S100A9	activates	gene	0.60
IL6	expressed_in	gene	0.60
HIF1	inhibits	gene	0.60
HIF1A	inhibits	gene	0.60
AGING	inhibits	gene	0.60
MICRORNAS	inhibits	gene	0.60
MIR-369-3P	inhibits	gene	0.60
RAGE	activates	gene	0.60
IL6	activates	gene	0.60
SYNAPSE	associated_with	gene	0.60
GFAP	biomarker_for	gene	0.60
IL-1	biomarker_for	gene	0.60
CYTOKINES	biomarker_for	gene	0.60
IBA1	biomarker_for	gene	0.60
IL-6	biomarker_for	gene	0.60
MICROGLIA	therapeutic_target	gene	0.60
STROKE	therapeutic_target	gene	0.60
IL-33	activates	gene	0.60
TSLP	activates	gene	0.60
STROKE	biomarker_for	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
RIPK1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning INTERLEUKIN in their description or question text

No additional research found