Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IL3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
IL3 encodes Interleukin-3, a hematopoietic cytokine involved in immune cell development and neuroinflammation in neurodegenerative diseases including Alzheimer's and Parkinson's.
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| Gene Symbol | IL3 |
| Full Name | Interleukin 3 |
| Chromosome | 5q31.1 |
| Protein Family | IL-3 cytokine family |
| Function | is a secreted cytokine with a characteristic four-helix bundle structure |
| Primary Expression | the brain by neurons, astrocytes, microglia, and endothelial cells, where they participate in neuroinflammatory processes relevant to neurodegenerativ |
| Molecular Weight | 17 kDa |
| Amino Acids | 152 aa |
| Exons | 5 |
| UniProt ID | P08700 |
| NCBI Gene ID | 3562 |
| Ensembl ID | ENSG00000164399 |
| OMIM | 147740 |
| GeneCards | IL3 |
| Human Protein Atlas | IL3 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Interactions | CAMKII, CCND1, CYTOKINES, GNAL, IL1B, IL8 |
| KG Connections | 11 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["IL3"]
N1["Als"]
N0 -->|"inhibits"| N1
N2["IL1B"]
N0 -->|"inhibits"| N2
N3["CAMKII"]
N0 -->|"inhibits"| N3
N4["CCND1"]
N0 -->|"inhibits"| N4
N5["CYTOKINES"]
N0 -->|"inhibits"| N5
N6["GNAL"]
N0 -->|"inhibits"| N6
N7["IL8"]
N0 -->|"inhibits"| N7
N8["Rb"]
N0 -->|"inhibits"| N8
N9["TNF"]
N9 -->|"inhibits"| N0
N10["neurodegeneration"]
N0 -->|"implicated in"| N10
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classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 disease
class N2 gene
class N3 gene
class N4 gene
class N5 gene
class N6 gene
class N7 gene
class N8 protein
class N9 geneHypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning IL3 in their description or question text
No additional research found