| Gene Symbol | IKBKE |
| Full Name | Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Epsilon |
| Chromosome | 1q31.3 |
| Protein Type | Kinase |
| Function | IKBKE is a non-canonical IKK family member that phosphorylates IκB proteins and activates NF-κB signaling, but also has IκB-independent functions[@hemmings2007]: |
| Primary Expression | breast cancer[@hershko2004] - Tumor Survival: Promotes tumor cell survival and proliferation - Metastasis: Associated with metastatic potentia |
| Pathways | NF-κB, NF-κB signaling |
| UniProt ID | Q14164 |
| NCBI Gene ID | 9641 |
| Ensembl ID | ENSG00000105468 |
| OMIM | 605048 |
| GeneCards | IKBKE |
| Human Protein Atlas | IKBKE |
| IκB Phosphorylation | Phosphorylates IκBα and IκBβ, leading to NF-κB activation |
| IKK Complex | Can form complexes with IKKγ/NEMO for NF-κB signaling |
| Associated Diseases | Infection, Inflammation |
| Interactions | AND, ATG8, AUTOPHAGY, CALCOCO2, INFLAMMATION, MAVS |
| KG Connections | 96 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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