gene

SIRT7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SIRT7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

138Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

SIRT7 sirtuin - structure, function, role in ribosome biogenesis, stress response, neurodegeneration, Alzheimer's disease, Parkinson's disease

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🧬 Gene Info

Gene Symbol	SIRT7
Full Name	Sirtuin 7 (Nuclear NAD-dependent deacetylase)
Aliases	SIRT7 sirtuin
Chromosome	17q25.3
Function	is a NAD+-dependent nuclear class III deacetylase predominantly localized to nucleoli where it regulates ribosomal RNA transcription and ribosome biogenesis.
Primary Expression	High in brain (cortex, hippocampus, substantia nigra), heart, liver
Subcellular Localization	nucleoli where it regulates ribosomal RNA transcription and ribosome biogenesis. It is the least characterized mammalian
Molecular Weight	44 kDa
Amino Acids	400 aa
Pathways	Apoptosis, Autophagy, Mtor, Oxidative Stress
UniProt ID	Q9H0U6
NCBI Gene ID	23433
Ensembl ID	ENSG00000117595
OMIM	613213
GeneCards	SIRT7
Human Protein Atlas	SIRT7
Associated Diseases	Aging, Cancer, Neurodegeneration
Interactions	AMPK, ATP, CDK2, DDX3X, ERK1/2, FBXO7
KG Connections	138 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SIRT7 — AlphaFold Q9H0U6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SIRT7 Gene

gene · 1605 words

→

SIRT7 Protein

protein · 607 words

→

Pathway Diagram

graph TD
    SIRT7["SIRT7"]
    Senescence{"Senescence"}
    SIRT7 -->|"therapeutic target"| Senescence
    Cardiovascular{"Cardiovascular"}
    SIRT7 -->|"therapeutic target"| Cardiovascular
    Neurodegeneration{"Neurodegeneration"}
    SIRT7 -->|"regulates"| Neurodegeneration
    Parkinson{"Parkinson"}
    SIRT7 -->|"regulates"| Parkinson
    Alzheimer{"Alzheimer"}
    SIRT7 -->|"regulates"| Alzheimer
    Neuroinflammation{"Neuroinflammation"}
    SIRT7 -->|"regulates"| Neuroinflammation
    Inflammation{"Inflammation"}
    SIRT7 -->|"regulates"| Inflammation
    Huntington{"Huntington"}
    SIRT7 -->|"regulates"| Huntington
    Ms{"Ms"}
    SIRT7 -->|"regulates"| Ms
    SIRT7 -->|"regulates"| Cardiovascular
    SIRT7 -->|"regulates"| Senescence
    Als{"Als"}
    SIRT7 -->|"expressed in"| Als
    DNA["DNA"]
    DNA -->|"therapeutic target"| SIRT7
    SIRT6["SIRT6"]
    SIRT6 -->|"expressed in"| SIRT7
    HDAC11["HDAC11"]
    HDAC11 -->|"regulates"| SIRT7
    HDAC2["HDAC2"]
    HDAC2 -->|"regulates"| SIRT7
    SIRT1["SIRT1"]
    SIRT1 -->|"regulates"| SIRT7
    BDNF["BDNF"]
    BDNF -->|"regulates"| SIRT7
    HDAC3["HDAC3"]
    HDAC3 -->|"regulates"| SIRT7
    SIRT5["SIRT5"]
    SIRT5 -->|"expressed in"| SIRT7
    HDAC7["HDAC7"]
    HDAC7 -->|"regulates"| SIRT7
    SIRT4["SIRT4"]
    SIRT4 -->|"expressed in"| SIRT7
    AGING["AGING"]
    AGING -->|"associated with"| SIRT7
    SIRT6 -->|"interacts with"| SIRT7
    style SIRT7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (88)

Target	Relation	Type	Str
SIRT5	expressed_in	gene	0.70
OXIDATIVE STRESS	regulates	gene	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
Senescence	therapeutic_target	disease	0.65
Cardiovascular	regulates	disease	0.65
Autoimmune	expressed_in	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Senescence	regulates	disease	0.65
Inflammation	expressed_in	disease	0.65
Alzheimer	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Aging	associated_with	disease	0.65
Ms	interacts_with	disease	0.65
Cancer	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Inflammation	regulates	disease	0.65
Huntington	regulates	disease	0.65
Ms	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Als	expressed_in	disease	0.65
Parkinson	regulates	disease	0.65
Tumor	interacts_with	disease	0.65
Aging	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
SIRT1	expressed_in	gene	0.60
HDAC1	regulates	gene	0.60
SIRT2	expressed_in	gene	0.60
SIRT3	expressed_in	gene	0.60
HDAC3	regulates	gene	0.60
HDAC6	regulates	gene	0.60
SIRT4	expressed_in	gene	0.60
HDAC7	regulates	gene	0.60
RANK	interacts_with	gene	0.60
SIRT1	interacts_with	gene	0.60
CDK2	associated_with	gene	0.60
PTK2	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
SIRT6	interacts_with	gene	0.60
HUNTINGTON	regulates	gene	0.60
HDAC	associated_with	gene	0.60
NEURODEGENERATIVE DISORDERS	regulates	gene	0.60
AND	expressed_in	gene	0.60
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
MITOCHONDRIA	expressed_in	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
Mtor	interacts_with	pathway	0.60
Lipid Metabolism	interacts_with	pathway	0.60

Incoming (50)

Source	Relation	Type	Str
SIRT6	expressed_in	gene	0.70
SIRT2	expressed_in	gene	0.70
SIRT3	expressed_in	gene	0.70
SIRT1	expressed_in	gene	0.70
SIRT4	expressed_in	gene	0.70
HDAC3	regulates	gene	0.60
SIRT5	expressed_in	gene	0.60
HDAC7	regulates	gene	0.60
SIRT6	interacts_with	gene	0.60
MTOR	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
NEURODEGENERATIVE DISORDERS	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
HUNTINGTON	regulates	gene	0.60
BDNF	regulates	gene	0.60
MITOCHONDRIA	expressed_in	gene	0.60
HDAC11	regulates	gene	0.60
HDAC2	regulates	gene	0.60
SIRT1	regulates	gene	0.60
DDX3X	inhibits	gene	0.60
NAD	regulates	gene	0.60
TAU	regulates	gene	0.60
HDAC6	regulates	gene	0.60
HDAC1	regulates	gene	0.60
DNA	therapeutic_target	gene	0.60
APOPTOSIS	regulates	gene	0.60
DNA	regulates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
NAD	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
OXIDATIVE STRESS	expressed_in	gene	0.60
CDK2	interacts_with	gene	0.60
SIRT6	inhibits	gene	0.60
PTK2	interacts_with	gene	0.60
SIRT1	interacts_with	gene	0.60
SIRT6	regulates	gene	0.60
FBXO7	regulates	gene	0.60
FBXO7	activates	gene	0.60
FBXO7	implicated_in	gene	0.60
AGING	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
SIRT6	activates	gene	0.55
ATP	activates	gene	0.55
NAD	activates	gene	0.55
NADH	activates	gene	0.55
SIRT1	activates	gene	0.55
AMPK	activates	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity