Contents

HDAC1 Gene

🧬 Gene Info

Gene Symbol	HDAC1
Chromosome	1p35.2-p35.1<br>
Function	HDAC1 functions as a transcriptional repressor by deacetylating histone H3 and H4 tails, leading to chromatin compaction and reduced gene expression.
Primary Expression	the brain with high levels in: - Hippocampus (CA1-CA3 pyramidal neurons) - Cerebral cortex (lay
Molecular Weight	55 kDa
Pathways	NF-κB
UniProt ID	Q13547
NCBI Gene ID	3065
Ensembl ID	ENSG00000100994
GeneCards	HDAC1
Human Protein Atlas	HDAC1
Chromatin Compaction	Deacetylates histones to promote heterochromatin formation
Transcriptional Repression	Part of Sin3A, CoREST, and NuRD complexes
Cell Cycle Regulation	Controls expression of cell cycle regulators
DNA Damage Response	Regulates DNA repair gene expression
Associated Diseases	Alzheimer, disease, synaptic dysfunction
Known Drugs/Compounds	BORTEZOMIB
Interactions	AKT, AND, APOPTOSIS, App, AUTOPHAGY, BCL-2
SciDEX Hypotheses	Microglial Priming Window for HDAC1-Dependent DAM
KG Connections	336 knowledge graph edges
Databases	GeneCards HPA STRING

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Knowledge Graph

GATA4 interacts_with HDAC1

HDAC1 modifies p65

SIRT6 regulates HDAC1

HDAC11 expressed_in HDAC1

HDAC2 expressed_in HDAC1

SIRT7 regulates HDAC1

SIRT5 regulates HDAC1

BDNF regulates HDAC1

SIRT1 regulates HDAC1

HDAC1 regulates SIRT2