Contents

HDAC1 Protein

🔬 Protein Info

Gene Symbol	HDAC1
Aliases	HDAC1PROTEIN
Chromosome	1p35.2-p35.1<br>
Function	HDAC1 functions as a transcriptional repressor by deacetylating histone H3 and H4 tails, leading to chromatin compaction and reduced gene expression.
Primary Expression	the brain with high levels in: - Hippocampus (CA1-CA3 pyramidal neurons) - Cerebral cortex (lay
Subcellular Localization	</strong></td><td>Nucleus</td></tr>
Molecular Weight	55 kDa
Pathways	NF-κB
UniProt ID	Q13547
NCBI Gene ID	3065
Ensembl ID	ENSG00000100994
GeneCards	HDAC1
Human Protein Atlas	HDAC1
Zn²⁺-dependent hydrolase	Requires zinc ion for catalytic activity
Residues 1-375	Form the deacetylase core
Associated Diseases	Alzheimer, disease, synaptic dysfunction
Known Drugs/Compounds	BORTEZOMIB
Interactions	AKT, AND, APOPTOSIS, App, AUTOPHAGY, BCL-2
SciDEX Hypotheses	Microglial Priming Window for HDAC1-Dependent DAM
KG Connections	336 knowledge graph edges
Databases	GeneCards HPA STRING

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