gene

DUSP2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DUSP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections

0Hypotheses

0Analyses

15Outgoing

1Incoming

0Experiments

0Debates

Summary

Page for DUSP2 Gene

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🧬 Gene Info

Gene Symbol	DUSP2
Protein Type	Phosphatase
Function	is a member of the dual-specificity phosphatase family that dephosphorylates both tyrosine and threonine residues on MAP kinases.
Primary Expression	immune cells and has been increasingly studied for its role in neuroinflammatory and neurodegenerative processes [1][2]
Amino Acids	189 aa
Pathways	MAPK signaling, MAPK, NF-κB
Ensembl ID	ENSG00000158050
GeneCards	DUSP2
Human Protein Atlas	DUSP2
Associated Diseases	ALS, Alzheimer, dementia
Interactions	CANCER, ERK, HDAC, HDAC1, MMP2
KG Connections	16 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DUSP2 Gene

gene · 1095 words

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Pathway Diagram

graph TD
    DUSP2["DUSP2"]
    Carcinoma{"Carcinoma"}
    DUSP2 -->|"activates"| Carcinoma
    Cancer{"Cancer"}
    DUSP2 -->|"activates"| Cancer
    Als{"Als"}
    DUSP2 -->|"activates"| Als
    ERK["ERK"]
    DUSP2 -->|"activates"| ERK
    HDAC1["HDAC1"]
    DUSP2 -->|"activates"| HDAC1
    CANCER["CANCER"]
    DUSP2 -->|"activates"| CANCER
    HDAC["HDAC"]
    DUSP2 -->|"activates"| HDAC
    AND["AND"]
    AND -->|"activates"| DUSP2
    MMP2["MMP2"]
    MMP2 -->|"activates"| DUSP2
    GENES["GENES"]
    DUSP2 -->|"co_discussed"| GENES
    NEURON["NEURON"]
    DUSP2 -->|"co_discussed"| NEURON
    VAMP3["VAMP3"]
    DUSP2 -->|"co_discussed"| VAMP3
    neurodegeneration["neurodegeneration"]
    DUSP2 -->|"implicated_in"| neurodegeneration

Outgoing (15)

Target	Relation	Type	Str
Carcinoma	activates	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
ERK	activates	gene	0.60
CANCER	activates	gene	0.60
HDAC	activates	gene	0.60
ALS	associated_with	disease	0.60
dementia	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
HDAC1	activates	gene	0.60
neurodegeneration	targets	disease	0.60
neuroinflammation	targets	disease	0.60
VAMP3	co_discussed	gene	0.50
GENES	co_discussed	gene	0.50
NEURON	co_discussed	gene	0.50

Incoming (1)

Source	Relation	Type	Str
MMP2	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DUSP2 in their description or question text

No additional research found