gene

VGF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VGF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

118Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

VGF is a gene implicated in neurodegeneration research. Key relationships include: implicated in, associated with, biomarker for. Associated with AD, ALI, Als. Connected to 49 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	VGF
Chromosome	7q22.1
Primary Expression	neurons of the central and peripheral nervous systems
Molecular Weight	~68 kDa
Amino Acids	617 aa
Pathways	MAPK pathway, PI3K, AMPK pathway
UniProt ID	Q9UK23
NCBI Gene ID	5139
GeneCards	VGF
Human Protein Atlas	VGF
Neuronal development	Promotes neuronal survival and differentiation
Synaptic plasticity	Regulates synaptic function and memory formation
Energy homeostasis	Controls appetite and metabolism
Disease associations	Alzheimer's disease, depression, cachexia, neurodegenerative disorders
Protein Length	617 amino acids
Associated Diseases	AD, ALI, Als, Alzheimer, Alzheimer's disease
Interactions	AMYLOID, BDNF, CST3, CTSB, CTSD, CTSS
KG Connections	118 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: VGF — AlphaFold Q9UK23 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    VGF["VGF"]
    Alzheimer{"Alzheimer"}
    VGF -->|"biomarker for"| Alzheimer
    Ms{"Ms"}
    VGF -->|"biomarker for"| Ms
    VGF -->|"associated with"| Alzheimer
    VGF -->|"expressed in"| Ms
    Cancer{"Cancer"}
    VGF -->|"expressed in"| Cancer
    Tumor{"Tumor"}
    VGF -->|"expressed in"| Tumor
    Schizophrenia{"Schizophrenia"}
    VGF -->|"expressed in"| Schizophrenia
    NTN1["NTN1"]
    VGF -->|"associated with"| NTN1
    GPNMB["GPNMB"]
    VGF -->|"associated with"| GPNMB
    NPTX2["NPTX2"]
    VGF -->|"associated with"| NPTX2
    Amyloid(["Amyloid"])
    VGF -->|"associated with"| Amyloid
    HDAC1["HDAC1"]
    VGF -->|"activates"| HDAC1
    GPNMB -->|"associated with"| VGF
    NPTX2 -->|"associated with"| VGF
    NTN1 -->|"associated with"| VGF
    CANCER["CANCER"]
    CANCER -->|"expressed in"| VGF
    HSPA1A["HSPA1A"]
    HSPA1A -->|"activates"| VGF
    PI3K["PI3K"]
    PI3K -->|"expressed in"| VGF
    AMYLOID["AMYLOID"]
    AMYLOID -->|"biomarker for"| VGF
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"biomarker for"| VGF
    style VGF fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (67)

Target	Relation	Type	Str
Alzheimer'S Disease	associated_with	disease	0.85
ALZHEIMER'S DISEASE	associated_with	entity	0.80
Ms	biomarker_for	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Als	associated_with	disease	0.65
Als	activates	disease	0.65
Glioblastoma	activates	disease	0.65
Schizophrenia	expressed_in	disease	0.65
Tumor	activates	disease	0.65
Tumor	expressed_in	disease	0.65
Ms	regulates	disease	0.65
Depression	inhibits	disease	0.65
Alzheimer	regulates	disease	0.65
Ms	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Alzheimer	associated_with	disease	0.65
Amyloid	associated_with	pathway	0.60
CTSD	inhibits	gene	0.60
Akt	regulates	pathway	0.60
Pi3K	expressed_in	pathway	0.60
GLIOBLASTOMA	activates	gene	0.60
Stem Cell	expressed_in	pathway	0.60
NGF	activates	gene	0.60
Epigenetic	regulates	pathway	0.60
BDNF	regulates	gene	0.60
VEGF	regulates	gene	0.60
CTSB	inhibits	gene	0.60
GPNMB	associated_with	gene	0.60
NPTX2	associated_with	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
AMYLOID	biomarker_for	gene	0.60
AND	associated_with	gene	0.60
Microglia	associated_with	cell_type	0.60
NTN1	associated_with	gene	0.60
App	biomarker_for	protein	0.60
SYNAPSE	inhibits	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
neurodegeneration	biomarker_for	disease	0.60
oxidative stress response	participates_in	pathway	0.60
ALZHEIMER	biomarker_for	gene	0.60
PTN	associated_with	gene	0.60
Amyloid	biomarker_for	pathway	0.60
DEPRESSION	inhibits	gene	0.60
NEURODEGENERATIVE DISORDERS	regulates	gene	0.60
EXERCISE	activates	gene	0.60
ALZHEIMER	regulates	gene	0.60
AND	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
Neurotrophin Signaling	inhibits	pathway	0.60
Neurogenesis	inhibits	pathway	0.60

Incoming (51)

Source	Relation	Type	Str
NPAS3	regulates	gene	0.80
CANCER	expressed_in	gene	0.60
GPNMB	associated_with	gene	0.60
NPTX2	associated_with	gene	0.60
NTN1	associated_with	gene	0.60
GPNMB	interacts_with	gene	0.60
NPTX2	interacts_with	gene	0.60
NTN1	interacts_with	gene	0.60
VAMP4	associated_with	gene	0.60
VAMP7	associated_with	gene	0.60
ATG5	regulates	gene	0.60
VAMP2	regulates	gene	0.60
LAMP1	interacts_with	gene	0.60
LRRK2	expressed_in	gene	0.60
VAMP4	expressed_in	gene	0.60
VAMP7	expressed_in	gene	0.60
LRRK2	regulates	gene	0.60
VAMP4	regulates	gene	0.60
VAMP7	regulates	gene	0.60
AMYLOID	biomarker_for	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
PTN	associated_with	gene	0.60
HSPA1A	activates	gene	0.60
PI3K	expressed_in	gene	0.60
APOE	associated_with	gene	0.60
PIN1	associated_with	gene	0.60
RPL24	associated_with	gene	0.60
CD44	associated_with	gene	0.60
RPS23	associated_with	gene	0.60
GFAP	expressed_in	gene	0.60
MYT1L	associated_with	gene	0.60
APP	expressed_in	gene	0.60
AMYLOID	inhibits	gene	0.60
PTN	interacts_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
MICRORNAS	associated_with	gene	0.60
AMYLOID	associated_with	gene	0.60
CST3	inhibits	gene	0.60
CTSS	inhibits	gene	0.60
NPTX1	regulates	gene	0.60
SERPINA3	inhibits	gene	0.60
NRXN2	regulates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
HSPB1	expressed_in	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
NPTX2	co_discussed	protein	0.50
NTN1	co_discussed	gene	0.50
GPNMB	co_discussed	protein	0.50
ALZHEIMER	co_discussed	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

VGF