gene

GDNF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GDNF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

850Connections

2Hypotheses

8Analyses

50Outgoing

50Incoming

0Experiments

8Debates

Summary

Page for GDNF — Glial Cell Line-Derived Neurotrophic Factor

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🧬 Gene Info

Gene Symbol	GDNF
Aliases	Glial Cell Line-Derived Neurotrophic Factor
Protein Family	GDNF family (TGF-β superfamily)
Function	Maintains tyrosine hydroxylase expression
Primary Expression	Secreted, Extracellular space
Subcellular Localization	Secreted, Extracellular space
Molecular Weight	15 kDa
Pathways	PI3K, MAPK, TGF-β
UniProt ID	P39905
GeneCards	GDNF
Human Protein Atlas	GDNF
Primary Target	Dopaminergic neurons in the nigrostriatal pathway
Modality	AAV2/5-delivered synthetic gene circuit encoding GDNF under a feedback-controlled promoter
Circuit Logic	Dopamine-responsive element (DRE) linked to GDNF expression cassette with tetracycline-OFF safety switch
Delivery	Bilateral intraputaminal MRI-guided stereotactic injection (established neurosurgical technique)
Associated Diseases	Als, Alzheimer, Amyotrophic Lateral Sclerosis, Anxiety, CYTOKINES
Known Drugs/Compounds	levodopa, rapamycin, trehalose
Interactions	ACLY, ADCY3, AKT, ALOX15, ALPHA-SYNUCLEIN, ALZHEIMER
SciDEX Hypotheses	GDNF Gradient Establishment by Schwann Cells Enabl
KG Connections	738 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: GDNF — AlphaFold P39905 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    GDNF["GDNF"] -.->|"inhibits"| Dopamine["Dopamine"]
    GDNF["GDNF"] -->|"activates"| Dopamine["Dopamine"]
    GDNF["GDNF"] -->|"interacts with"| Dopamine["Dopamine"]
    GDNF["GDNF"] -->|"therapeutic target"| Dopamine["Dopamine"]
    Dopamine["Dopamine"] -->|"interacts with"| GDNF["GDNF"]
    GDNF["GDNF"] -.->|"inhibits"| Als["Als"]
    GDNF["GDNF"] -->|"activates"| Als["Als"]
    GDNF["GDNF"] -->|"associated with"| NEURODEGENERATION["NEURODEGENERATION"]
    GDNF["GDNF"] -->|"associated with"| TNF["TNF"]
    GDNF["GDNF"] -->|"associated with"| MITOCHONDRIA["MITOCHONDRIA"]
    GDNF["GDNF"] -->|"associated with"| TAU["TAU"]
    GDNF["GDNF"] -->|"associated with"| GFAP["GFAP"]
    style GDNF fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Dopamine fill:#006494,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style NEURODEGENERATION fill:#006494,stroke:#333,color:#e0e0e0
    style TNF fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style MITOCHONDRIA fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style TAU fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style GFAP fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (561)

Target	Relation	Type	Str
Neural Stem Cell Differentiation	regulates	process	0.90
neurons	expressed_in	cell_type	0.90
neurotrophin signaling	participates_in	pathway	0.85
astrocytes	expressed_in	cell_type	0.85
PARKINSON'S DISEASE	treats	disease	0.85
Parkinson's disease	activates	disease	0.80
brain health	promotes	biological_process	0.80
neurons	associated_with	cell_type	0.80
neurons	activates	cell_type	0.80
RET	activates	gene	0.80
neurons	protects_against	cell_type	0.80
IL-10	activates	gene	0.75
unfolded protein response	participates_in	pathway	0.75
NEURODEGENERATION	protects_against	disease	0.75
TGF-beta signaling	participates_in	pathway	0.75
Dopamine	therapeutic_target	entity	0.70
Dopamine	interacts_with	entity	0.70
dopaminergic neurons	protects_against	cell_type	0.70
Dopamine	inhibits	entity	0.70
RET	regulates	gene	0.70
NGF	regulates	gene	0.70
brainstem	expressed_in	brain_region	0.70
neurodegeneration	regulates	disease	0.70
neurons	regulates	cell_type	0.70
neural stem cells	activates	cell_type	0.70
HDAC1	inhibits	gene	0.70
Dopamine	activates	entity	0.70
BRAINSTEM	activates	brain_region	0.70
neurodegeneration	interacts_with	disease	0.70
oxidative stress response	participates_in	pathway	0.70
BRAINSTEM	treats	brain_region	0.70
T cells	expressed_in	cell_type	0.70
GFRA1	interacts_with	gene	0.70
GFAP	associated_with	gene	0.65
TAU	associated_with	gene	0.65
NGF	associated_with	gene	0.65
TNF	associated_with	gene	0.65
NEURONS	associated_with	cell_type	0.65
ALS	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
DOPAMINERGIC NEURONS	treats	cell_type	0.65
DEPRESSION	treats	disease	0.65
NEURODEGENERATION	degrades	disease	0.65
Als	associated_with	disease	0.65
STRIATUM	associated_with	brain_region	0.65
MITOCHONDRIAL DYSFUNCTION	interacts_with	phenotype	0.65
NEUROINFLAMMATION	protects_against	phenotype	0.65
ATP	treats	phenotype	0.65
STRIATUM	encodes	brain_region	0.65
MITOCHONDRIAL DYSFUNCTION	produces	phenotype	0.65

Incoming (289)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	1.00
PARKINSON'S DISEASE	associated_with	disease	0.96
h-47ab2be5	targets	hypothesis	0.90
AAV	transports	drug	0.85
BDNF	protects_against	gene	0.85
BDNF	associated_with	gene	0.82
AMYLOID	associated_with	gene	0.82
GLP-1	upregulates	protein	0.80
TREHALOSE	protects_against	drug	0.70
ASTROCYTE	protects_against	cell_type	0.70
TREHALOSE	associated_with	drug	0.70
Dopamine	interacts_with	entity	0.70
BDNF	expressed_in	gene	0.70
BDNF	activates	gene	0.66
ALS	associated_with	gene	0.66
APOPTOSIS	associated_with	gene	0.66
BDNF	inhibits	gene	0.66
ERK	activates	gene	0.65
APP	associated_with	gene	0.65
rapamycin	targets	drug	0.65
MICROGLIA	regulates	cell_type	0.65
NEURONS	treats	cell_type	0.65
AQP4	associated_with	gene	0.65
INFLAMMATION	regulates	phenotype	0.65
CNTF	associated_with	gene	0.65
HEDGEHOG SIGNALING	protects_against	pathway	0.65
ASTROCYTE	associated_with	gene	0.65
AUTOPHAGY	associated_with	gene	0.65
AKT	co_discussed	gene	0.65
STRIATUM	activates	brain_region	0.65
AMPK	associated_with	gene	0.65
RET	regulates	gene	0.60
GFRAL	activates	gene	0.60
LMX1A	activates	gene	0.60
PRKN	activates	gene	0.60
GFRAL	associated_with	gene	0.60
FGF2	associated_with	gene	0.60
GFRAL	inhibits	gene	0.60
AUTOPHAGY	activates	gene	0.60
C-JUN	activates	gene	0.60
PUERARIN	activates	gene	0.60
ANXIETY	associated_with	gene	0.60
GLP1R	inhibits	gene	0.60
BDNF	inhibits	gene	0.60
AMYLOID-BETA	expressed_in	gene	0.60
AMYLOID	inhibits	gene	0.60
YAP	activates	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
HUNTINGTON	therapeutic_target	gene	0.60
ALZHEIMER	activates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
GDNF Gradient Establishment by Schwann Cells Enables Motor R	0.610	neurodegeneration	What molecular mechanisms enable functio
GDNF-RET Trophic Signaling Deficit	0.530	neurodegeneration	Which specific factors in conditioned me

Mentioning Analyses (8)

Scientific analyses that reference this entity

Epigenetic reprogramming in aging neurons

neurodegeneration | 2026-04-04 | 9 hypotheses Top: 0.914

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

neurodegeneration | 2026-04-03 | 44 hypotheses Top: 0.990

Epigenetic clocks and biological aging in neurodegeneration

neurodegeneration | 2026-04-01 | 6 hypotheses Top: 0.710

Mitochondrial transfer between astrocytes and neurons

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.813

Neuroinflammation resolution mechanisms and pro-resolving mediators

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.784

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (8)

Multi-agent debates referencing this entity

Epigenetic reprogramming in aging neurons

closed · Rounds: 4 · Score: 0.95 · 2026-04-10

Astrocyte reactivity subtypes in neurodegeneration

closed · Rounds: 4 · Score: 0.95 · 2026-04-10

Anti-amyloid antibodies (lecanemab, donanemab) have ~0.1% brain penetrance. Engi

closed · Rounds: 4 · Score: 0.91 · 2026-04-06

Microglia activate astrocytes via IL-1alpha/TNF/C1q, and reactive astrocytes fee

closed · Rounds: 4 · Score: 0.90 · 2026-04-06

SPMs (resolvins, protectins, maresins) from omega-3s may promote inflammation re

closed · Rounds: 4 · Score: 0.83 · 2026-04-06

Mitochondrial transfer between astrocytes and neurons

closed · Rounds: 4 · Score: 0.95 · 2026-04-06

Epigenetic clocks and biological aging in neurodegeneration

closed · Rounds: 4 · Score: 0.93 · 2026-04-06

What gene expression changes in the aging mouse brain predict neurodegenerative

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning GDNF in their description or question text

No additional research found

GDNF

Understanding Entity Pages

Summary

Wiki Pages (21)

Synthetic Gene Circuit for Feedback-Controlled GDNF Delivery

GDNF Family Neurotrophic Factor Signaling Pathway in Neurodegeneration

GDNF Neurons

GDNF Signaling Pathway in Neurodegeneration

PD Neurotrophin/GDNF Delivery Companies

AB-1005 (REGENERATE-PD) GDNF Gene Therapy Trial

Pathway Diagram

Outgoing (561)

Incoming (289)

Targeting Hypotheses (2)

Mentioning Analyses (8)

Epigenetic reprogramming in aging neurons

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Epigenetic clocks and biological aging in neurodegeneration

Mitochondrial transfer between astrocytes and neurons

Neuroinflammation resolution mechanisms and pro-resolving mediators

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

Astrocyte reactivity subtypes in neurodegeneration

Blood-brain barrier transport mechanisms for antibody therapeutics

Experiments (0)

Related Papers (0)

Debates (8)

Epigenetic reprogramming in aging neurons

Astrocyte reactivity subtypes in neurodegeneration

Anti-amyloid antibodies (lecanemab, donanemab) have ~0.1% brain penetrance. Engi

Microglia activate astrocytes via IL-1alpha/TNF/C1q, and reactive astrocytes fee

SPMs (resolvins, protectins, maresins) from omega-3s may promote inflammation re

Mitochondrial transfer between astrocytes and neurons

Epigenetic clocks and biological aging in neurodegeneration

What gene expression changes in the aging mouse brain predict neurodegenerative

Related Research

GDNF

Understanding Entity Pages

Summary

Wiki Pages (21)

Synthetic Gene Circuit for Feedback-Controlled GDNF Delivery

GDNF Family Neurotrophic Factor Signaling Pathway in Neurodegeneration

GDNF Neurons

GDNF Signaling Pathway in Neurodegeneration

PD Neurotrophin/GDNF Delivery Companies

AB-1005 (REGENERATE-PD) GDNF Gene Therapy Trial

GFRA4 - GDNF Family Receptor Alpha 4

Artemin (ARTN) - GDNF Family Neurotrophic Factor Therapy

Glial Cell Line-Derived Neurotrophic Factor (GDNF) Therapies

Neurotrophic Factor Gene Therapy Programs — GDNF, CDNF, BDNF, Neurturin

GFRα3 Protein - GDNF Family Receptor Alpha 3

GFRα4 Protein - GDNF Family Receptor Alpha 4

GFRA2 - GDNF Family Receptor Alpha 2

Glial Cell Derived Neurotrophic Factor (GDNF)

GDNF (Glial Cell Line-Derived Neurotrophic Factor) Neurons

AB-1005 GDNF Gene Therapy Long-Term Follow-up Study

AB-1005 (REGENERATE-PD) GDNF Gene Therapy Trial

GFRα2 Protein - GDNF Family Receptor Alpha 2

GDNF Therapy for Parkinson's Disease

GDNF - Neurotrophic Factor Biomarker

GDNF — Glial Cell Line-Derived Neurotrophic Factor

Pathway Diagram

Outgoing (561)

Incoming (289)

Targeting Hypotheses (2)

Mentioning Analyses (8)

Epigenetic reprogramming in aging neurons

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Epigenetic clocks and biological aging in neurodegeneration

Mitochondrial transfer between astrocytes and neurons

Neuroinflammation resolution mechanisms and pro-resolving mediators

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

Astrocyte reactivity subtypes in neurodegeneration

Blood-brain barrier transport mechanisms for antibody therapeutics

Experiments (0)

Related Papers (0)

Debates (8)

Epigenetic reprogramming in aging neurons

Astrocyte reactivity subtypes in neurodegeneration

Anti-amyloid antibodies (lecanemab, donanemab) have ~0.1% brain penetrance. Engi

Microglia activate astrocytes via IL-1alpha/TNF/C1q, and reactive astrocytes fee

SPMs (resolvins, protectins, maresins) from omega-3s may promote inflammation re

Mitochondrial transfer between astrocytes and neurons

Epigenetic clocks and biological aging in neurodegeneration

What gene expression changes in the aging mouse brain predict neurodegenerative

Related Research