gene 885 words KG: GDNF
Contents

GDNF — Glial Cell Line-Derived Neurotrophic Factor

🧬 Gene Info
Gene SymbolGDNF
Full NameGlial Cell Line-Derived Neurotrophic Factor
Protein FamilyGDNF family (TGF-β superfamily)
FunctionMaintains tyrosine hydroxylase expression
Primary ExpressionSecreted, Extracellular space
Subcellular LocalizationSecreted, Extracellular space
Molecular Weight15 kDa
PathwaysPI3K, MAPK, TGF-β
UniProt IDP39905
GeneCardsGDNF
Human Protein AtlasGDNF
Associated DiseasesAls, Alzheimer, Amyotrophic Lateral Sclerosis, Anxiety, CYTOKINES
Known Drugs/Compoundslevodopa, rapamycin, trehalose
InteractionsACLY, ADCY3, AKT, ALOX15, ALPHA-SYNUCLEIN, ALZHEIMER
SciDEX HypothesesGDNF Gradient Establishment by Schwann Cells Enabl
KG Connections738 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (30)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.81
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Smartphone-Detected Motor Variability Correction
Score: 0.74

Related Analyses (26)

CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · completed
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (4)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Neural Stem Cell Therapy for Alzheimer's Disease
clinical · proposed · Score: 0.40
Selective Vulnerability of Dopaminergic Neurons — Mechanism
validation · proposed · Score: 0.40

See Also (6)

ABCA7 (Redirect)
redirect · KG edge: associated_with
acetylcholine
general · KG edge: co_discussed
ADCY3 — Adenylate Cyclase 3
gene · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
Packard Center for ALS Research
institution · KG edge: associated_with

Knowledge Graph (12 edges)

BDNF inhibits GDNF
GLP1R inhibits GDNF
GFRAL inhibits GDNF
GDNF inhibits Dopamine
GDNF activates Dopamine
GDNF interacts_with Dopamine
Dopamine interacts_with GDNF
GDNF therapeutic_target Dopamine
GDNF inhibits GFRAL
GDNF inhibits BDNF

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)