| Gene Symbol | ent-gene-6e1f0bee |
| PI3K/AKT pathway | Promotes cell survival through phosphorylation of BAD and activation of mTOR |
| MAPK/ERK pathway | Regulates neuronal differentiation and plasticity |
| PLCγ pathway | Modulates calcium signaling and synaptic transmission |
| STAT3 pathway | Controls gene expression related to cell survival and inflammation |
| Cortex | Layer 5 pyramidal neurons produce GDNF for corticospinal tract maintenance |
| Striatum | Medium spiny neurons provide trophic support to nigral dopamine neurons |
| Hippocampus | Dentate gyrus granule cells express GDNF for entorhinal cortex connections |
| Brainstem | Specific nuclei (e.g., red nucleus, vestibular nuclei) produce GDNF for descending pathways |
| Spinal cord | Interneurons support motor neuron survival |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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