gene

CNTF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CNTF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections

1Hypotheses

0Analyses

31Outgoing

12Incoming

0Experiments

0Debates

Summary

CNTF is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, inhibits, associated with. Associated with Autoimmune, Cancer, Infection. Connected to 12 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CNTF
Full Name	Ciliary Neurotrophic Factor
Chromosome	11q13.1
Protein Family	IL-6 family of cytokines
Function	is a neuroprotective cytokine belonging to the interleukin-6 (IL-6) family of cytokines.
Primary Expression	astrocytes throughout the brain and spinal cord - Peripheral nervous system: Expressed in Schwann cells and olfactory ensh
Molecular Weight	22.7 kDa
Amino Acids	200 aa
Pathways	JAK-STAT signaling, MAPK Pathway, PI3K, MAPK
UniProt ID	P26441
NCBI Gene ID	1270
Ensembl ID	ENSG00000261349
OMIM	118425
GeneCards	CNTF
Human Protein Atlas	CNTF
Associated Diseases	ALS, Alzheimer's disease, Parkinson's disease
Known Drugs/Compounds	metformin
Interactions	AMPK, AND, BDNF, CYTOKINES, EPILEPSY, GDNF
KG Connections	38 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CNTF — AlphaFold P26441 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CNTF["CNTF"]
    GDNF["GDNF"]
    CNTF -->|"associated_with"| GDNF
    Autoimmune{"Autoimmune"}
    CNTF -->|"therapeutic_target"| Autoimmune
    Cancer{"Cancer"}
    CNTF -->|"therapeutic_target"| Cancer
    Infection{"Infection"}
    CNTF -->|"therapeutic_target"| Infection
    Inflammation{"Inflammation"}
    CNTF -->|"therapeutic_target"| Inflammation
    BDNF["BDNF"]
    BDNF -->|"associated_with"| CNTF
    CANCER["CANCER"]
    CNTF -->|"therapeutic_target"| CANCER
    AND["AND"]
    CNTF -->|"inhibits"| AND
    CYTOKINES["CYTOKINES"]
    CNTF -->|"inhibits"| CYTOKINES
    LIF["LIF"]
    CNTF -->|"inhibits"| LIF
    IL_6["IL-6"]
    CNTF -->|"inhibits"| IL_6
    LIF -->|"inhibits"| CNTF
    CYTOKINES -->|"inhibits"| CNTF
    IL_6 -->|"inhibits"| CNTF
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"therapeutic_target"| CNTF

Outgoing (31)

Target	Relation	Type	Str
GDNF	associated_with	gene	0.65
Infection	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Epilepsy	activates	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Autoimmune	therapeutic_target	disease	0.65
Epilepsy	activates	disease	0.60
FGF	associated_with	gene	0.60
oxidative stress response	participates_in	pathway	0.60
LIF	inhibits	gene	0.60
Schwann Cell	transports	cell_type	0.60
Cntf	transports	protein	0.60
MBP	activates	gene	0.60
MOG	activates	gene	0.60
NGF	activates	gene	0.60
GSDMD	inhibits	gene	0.60
GDNF	protects_against	gene	0.60
NGF	associated_with	gene	0.60
CANCER	therapeutic_target	gene	0.60
ASTROCYTES	transports	gene	0.60
ASTROCYTE	transports	gene	0.60
EPILEPSY	activates	gene	0.60
Astrocyte	transports	cell_type	0.60
Neuron	transports	cell_type	0.60
Cytokine	transports	protein	0.60
AND	inhibits	gene	0.60
CYTOKINES	inhibits	gene	0.60
IL-6	inhibits	gene	0.60
neurotrophin signaling	participates_in	pathway	0.55
GDNF	activates	gene	0.55
microglia	expressed_in	cell_type	0.55

Incoming (12)

Source	Relation	Type	Str
BDNF	associated_with	gene	0.65
LIF	inhibits	gene	0.60
CYTOKINES	inhibits	gene	0.60
IL-6	inhibits	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
AMPK	activates	gene	0.60
metformin	targets	drug	0.60
CNTF	transports	gene	0.60
ASTROCYTES	transports	gene	0.60
ASTROCYTE	transports	gene	0.60
EPILEPSY	activates	gene	0.60
BDNF	activates	gene	0.55

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CNTF-JAK/STAT3 Reprogramming of Trained Microglia to Neuropr	0.522	neuroinflammation	What specific astrocyte-derived factors

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CNTF in their description or question text

No additional research found