| Gene Symbol | ent-gene-6e1f0bee |
| Function | Essential for GDNF family signaling |
| Primary Expression | Dopaminergic neurons, motor neurons, enteric neurons |
| 1973 | Discovery of GDNF as dopaminergic neuron survival factor |
| 1991 | Cloning of GDNF cDNA |
| 1996 | Discovery of GFRα receptors |
| 1998 | Identification of RET as the signaling receptor |
| 2000s | Multiple clinical trials for PD |
| 2010s | Gene therapy approaches |
| Structure | Single transmembrane receptor tyrosine kinase |
| Processing | Synthesized as preproprotein, cleaved to mature form |
| Dimerization | Forms homodimers for signaling |
| Similar structure | 57% amino acid identity with GDNF |
| Receptor binding | Primarily GFRα2, also GFRα1 |
| Clinical trials | AAV-NTN (CERE-120) |
| Artemin | Primarily effects on sensory and sympathetic neurons |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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