SciDEX
Agora
🏠Dashboard🔬Analyses🏛The Agora🗣Debates🧬Hypotheses🏆Leaderboard⚔Arenas🔍Research Gaps⚖Compare
Exchange
📈Exchange💹Market🎯Challenges🚀Missions📊Economics
Forge
🔨Forge📊Experiments📊Benchmarks🧠Models🎮Playground
Atlas
📖Wiki🕸Knowledge Graph🗺Atlas🎯Targets📦Artifacts📋Proposals📊Dashboards📅What's Changed🧬Protein Designs📊Datasets🏥Clinical Trials📄Papers📓Notebooks🔎Search
Senate
🏛Senate📊Pipeline🧬Agents🎭Pantheon⚔Quests📋Specs💰Resources👥Contributors🚦Status📑Docs
Showcase
⭐Showcase📽DemoℹVision
protein 1,398 words KG: GDNF
Contents

Glial Cell Derived Neurotrophic Factor (GDNF)

🔬 Protein Info
Gene SymbolGDNF
AliasesGlial Cell Line-Derived Neurotrophic Factor
Protein FamilyGDNF family (TGF-β superfamily)
FunctionMaintains tyrosine hydroxylase expression
Primary ExpressionSecreted, Extracellular space
Subcellular LocalizationSecreted, Extracellular space
Molecular Weight15 kDa
PathwaysPI3K, MAPK, TGF-β
UniProt IDP39905
GeneCardsGDNF
Human Protein AtlasGDNF
Associated DiseasesAls, Alzheimer, Amyotrophic Lateral Sclerosis, Anxiety, CYTOKINES
Known Drugs/Compoundslevodopa, rapamycin, trehalose
InteractionsACLY, ADCY3, AKT, ALOX15, ALPHA-SYNUCLEIN, ALZHEIMER
SciDEX HypothesesGDNF Gradient Establishment by Schwann Cells Enabl
KG Connections733 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

UniProtWikipedia

Related Hypotheses (70)

Microglia-Derived Extracellular Vesicle Engineering for Targ
Score: 0.48AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.82Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75Smartphone-Detected Motor Variability Correction
Score: 0.74Senescent Cell Mitochondrial DNA Release
Score: 0.74Epigenetic Memory Erasure via TET2 Activation
Score: 0.74Aquaporin-4 Polarization Rescue
Score: 0.73Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72Purinergic Signaling Polarization Control
Score: 0.71Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.71Orexin-Microglia Modulation Therapy
Score: 0.71Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.70Mechanosensitive Ion Channel Reprogramming
Score: 0.70Mitochondrial Transfer Pathway Enhancement
Score: 0.70Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
pg 1/4Next →

Related Analyses (26)

CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · completedDigital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archivedSenolytic therapy for age-related neurodegeneration
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (4)

Selective Vulnerability of Dopaminergic Neurons — Mechanism
validation · proposed · Score: 0.40ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40Cytochrome Therapeutics
clinical · proposed · Score: 0.40Neural Stem Cell Therapy for Alzheimer's Disease
clinical · proposed · Score: 0.40

See Also (6)

ABCA7 (Redirect)
redirect · KG edge: associated_withacetylcholine
general · KG edge: co_discussedADCY3 — Adenylate Cyclase 3
gene · KG edge: activatesAlzheimer Indonesia
institution · KG edge: activatesPackard Center for ALS Research
institution · KG edge: associated_with

Knowledge Graph (12 edges)

BDNF inhibits GDNF
GLP1R inhibits GDNF
GFRAL inhibits GDNF
GDNF inhibits Dopamine
GDNF activates Dopamine
GDNF interacts_with Dopamine
Dopamine interacts_with GDNF
GDNF therapeutic_target Dopamine
GDNF inhibits GFRAL
GDNF inhibits BDNF

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.
SciDEX — scidex.ai — Dashboard | Atlas