protein 1,145 words KG: SLC2A1PROTEIN
Contents

GLUT1 Protein (Glucose Transporter 1)

🔬 Protein Info
Gene SymbolSLC2A1
Full NameSolute Carrier Family 2 Member 1 (Glucose Transporter 1)
Chromosome1p34.2
Protein TypeTransporter
Functionis a facilitative glucose transporter belonging to the SLC2A family that provides the critical link between systemic glucose supply and cerebral energy metabolism.
Molecular Weight54 kDa
Amino Acids492 aa
Exons10
PathwaysFerroptosis, Mapk, Oxidative Stress, autophagy pathway, unfolded protein response
UniProt IDP11166
NCBI Gene ID6513
Ensembl IDENSG00000117394
OMIM138140
GeneCardsSLC2A1
Human Protein AtlasSLC2A1
Associated DiseasesAls, Ataxia, Cancer, Carcinoma, Infection, Ms
InteractionsABCB1, ABCG2, AGING, AKT1, ALZHEIMER, ALZHEIMER'S DISEASE
SciDEX HypothesesGLUT1-Mediated Glucose Flux Coefficient as Neuropr
KG Connections233 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (16)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Brain Insulin Resistance with Glucose Transporter Dysfunctio
Score: 0.60
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Retinal Vascular Microcirculation Rescue
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat
Score: 0.71
Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupli
Score: 0.67
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Metabolic reprogramming in neurodegenerative disease
neurodegeneration · completed

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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