gene 1,046 words KG: CFOS
Contents

CFOS Gene

🧬 Gene Info
Gene SymbolCFOS
Full NameFBJ murine osteosarcoma viral oncogene homolog
Chromosome14q24.3
Protein FamilyFos transcription factor family (c-Fos, FosB, Fra-1, Fra-2)
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight62 kDa
Amino Acids380 aa
Exons4 exons
PathwaysAmyloid, Blood-Brain Barrier
GeneCardsCFOS
Human Protein AtlasCFOS
Chromosomal location14q24.3
Gene length~9.5 kb
mRNA length~2.2 kb
Full nameFBJ murine osteosarcoma viral oncogene homolog
Associated Diseasesneurodegeneration
InteractionsALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APOE, APOE3
KG Connections43 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (10)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Gut Barrier Permeability-α-Synuclein Axis Modulation
Score: 0.53

Related Analyses (5)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
Genes
index · KG edge: activates
BDNF Gene
gene · KG edge: activates
DLK — Dual Leucine Zipper Kinase
gene · KG edge: activates
ERK1 (MAPK3) — Extracellular Signal-Regulated Kinase 1
gene · KG edge: activates

Knowledge Graph (12 edges)

ERK1 activates CFOS
CFOS activates DLK
CFOS activates APP
CFOS activates RANK
CFOS activates APOE4
CFOS activates APOE
APP activates CFOS
RANK activates CFOS
DLK activates CFOS
APOE activates CFOS

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