gene 695 words KG: FOS
Contents

FOS Gene

🧬 Gene Info
Gene SymbolFOS
Full NameFBJ Murine Osteosarcoma Viral Oncogene Homolog
Chromosome14q24.3
Protein TypeTranscription Factor
FunctionFOS is an immediate-early gene encoding a leucine zipper transcription factor.
Molecular Weight40.6 kDa
PathwaysImmune Response, Neurogenesis, Nf-Kb, Nf-Κb, Synaptic Plasticity
UniProt IDP01100
NCBI Gene ID2353
Ensembl IDENSG00000170345
OMIM164810
GeneCardsFOS
Human Protein AtlasFOS
Activity-dependent transcriptionResponds to neuronal firing and calcium influx
AP-1 complex formationHeterodimers with JUN family proteins (c-JUN, JUNB, JUND)
Associated DiseasesAls, Alzheimer, Atherosclerosis, Cancer, Ischemia, Ms
Known Drugs/Compoundspokeweed mitogen
InteractionsActin, AKT1, ALZHEIMER, ALZHEIMER'S DISEASE, AND, ANXIETY
KG Connections486 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (25)

Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66
Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.43
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.71
Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Extracellular Matrix Stiffness Modulation
Score: 0.69
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
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Related Analyses (8)

Epigenetic reprogramming in aging neurons
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

See Also (15)

Alzheimer Indonesia
institution · KG edge: associated_with
BCL2 Gene
gene · KG edge: therapeutic_target
AKT1 Gene
gene · KG edge: interacts_with
BMAL1 (ARNTL) Gene
gene · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: regulates

Knowledge Graph (12 edges)

FOS contributes_to AP1
EGF activates FOS
PIEZO1 activates FOS
SRC activates FOS
EGFR activates FOS
JUN activates FOS
pokeweed mitogen activates FOS
P38 activates FOS
FOS activates SRC
JUN interacts_with FOS

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