gene

CSF2RA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CSF2RA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

54Connections

0Hypotheses

0Analyses

34Outgoing

20Incoming

0Experiments

0Debates

Summary

CSF2RA encodes the alpha chain of the GM-CSF receptor, mediating cytokine signaling in microglia and immune cells

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🧬 Gene Info

Gene Symbol	CSF2RA
Full Name	Colony Stimulating Factor 2 Receptor Alpha Chain
Protein Type	Receptor
Function	is a critical cell surface receptor that mediates the pleiotropic effects of GM-CSF on myeloid lineage cells.
Molecular Weight	85 kDa
Amino Acids	90 aa
Exons	14
Pathways	Akt, Mapk, Pi3K, Pi3K/Akt
GeneCards	CSF2RA
Human Protein Atlas	CSF2RA
Associated Diseases	neurodegeneration
KG Connections	54 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CSF2RA — Colony Stimulating Factor 2 Receptor Alpha Chain

gene · 1774 words

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Pathway Diagram

graph TD
    CSF2RA["CSF2RA"]
    Als{"Als"}
    CSF2RA -->|"regulates"| Als
    ALS{"ALS"}
    CSF2RA -->|"regulates"| ALS
    S100A8["S100A8"]
    CSF2RA -->|"regulates"| S100A8
    Pi3K(["Pi3K"])
    CSF2RA -->|"regulates"| Pi3K
    Akt(["Akt"])
    CSF2RA -->|"regulates"| Akt
    Mapk(["Mapk"])
    CSF2RA -->|"regulates"| Mapk
    ERK["ERK"]
    CSF2RA -->|"regulates"| ERK
    NAMPT["NAMPT"]
    CSF2RA -->|"regulates"| NAMPT
    CSF2["CSF2"]
    CSF2RA -->|"regulates"| CSF2
    HSPA1A["HSPA1A"]
    CSF2RA -->|"regulates"| HSPA1A
    STAT1["STAT1"]
    CSF2RA -->|"regulates"| STAT1
    BCL_2["BCL-2"]
    CSF2RA -->|"regulates"| BCL_2
    CSF2 -->|"regulates"| CSF2RA
    NAMPT -->|"regulates"| CSF2RA
    FGF2["FGF2"]
    FGF2 -->|"regulates"| CSF2RA
    CXCL10["CXCL10"]
    CXCL10 -->|"regulates"| CSF2RA
    HSPA1A -->|"regulates"| CSF2RA
    FGF8["FGF8"]
    FGF8 -->|"regulates"| CSF2RA
    TLR4["TLR4"]
    TLR4 -->|"regulates"| CSF2RA
    ISG15["ISG15"]
    ISG15 -->|"regulates"| CSF2RA
    STAT1 -->|"regulates"| CSF2RA
    P38["P38"]
    P38 -->|"regulates"| CSF2RA
    ERK -->|"regulates"| CSF2RA
    PI3K["PI3K"]
    PI3K -->|"regulates"| CSF2RA
    style CSF2RA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (34)

Target	Relation	Type	Str
ALS	regulates	disease	0.65
Als	regulates	disease	0.65
Pi3K	regulates	pathway	0.60
Akt	regulates	pathway	0.60
BCL-2	regulates	gene	0.60
Mapk	regulates	pathway	0.60
ERK	regulates	gene	0.60
MAPK	regulates	gene	0.60
LGALS9	regulates	gene	0.60
Neutrophil	regulates	cell_type	0.60
Interferon	regulates	protein	0.60
Cytokine	regulates	protein	0.60
Fgf	regulates	protein	0.60
Ubiquitin	regulates	protein	0.60
NAMPT	regulates	gene	0.60
CSF2	regulates	gene	0.60
HSPA1A	regulates	gene	0.60
STAT1	regulates	gene	0.60
Rb	regulates	protein	0.60
TLR4	regulates	gene	0.60
HAVCR2	regulates	gene	0.60
CXCL10	regulates	gene	0.60
P38	regulates	gene	0.60
PI3K	regulates	gene	0.60
AKT	regulates	gene	0.60
FGF8	regulates	gene	0.60
ISG15	regulates	gene	0.60
FGF2	regulates	gene	0.60
EPOR	regulates	gene	0.60
EPO	regulates	gene	0.60
GENES	regulates	gene	0.60
S100A8	regulates	gene	0.60
Pi3K/Akt	regulates	pathway	0.60
CYTOKINE	regulates	concept	0.50

Incoming (20)

Source	Relation	Type	Str
LGALS9	regulates	gene	0.60
P38	regulates	gene	0.60
PI3K	regulates	gene	0.60
S100A8	regulates	gene	0.60
AKT	regulates	gene	0.60
EPO	regulates	gene	0.60
MAPK	regulates	gene	0.60
CSF2	regulates	gene	0.60
NAMPT	regulates	gene	0.60
FGF2	regulates	gene	0.60
CXCL10	regulates	gene	0.60
HSPA1A	regulates	gene	0.60
FGF8	regulates	gene	0.60
TLR4	regulates	gene	0.60
ISG15	regulates	gene	0.60
STAT1	regulates	gene	0.60
ERK	regulates	gene	0.60
GENES	regulates	gene	0.60
BCL-2	regulates	gene	0.60
EPOR	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CSF2RA in their description or question text

No additional research found