gene 1,055 words KG: ENO1
Contents

ENO1 Gene

🧬 Gene Info
Gene SymbolENO1
Full NameEnolase 1 (Alpha-enolase)
Chromosome1p36.23
Functionencodes a 433-amino acid protein (approximately 47 kDa).
Subcellular Localizationthe cell surface
Molecular Weight47 kDa
Amino Acids433 aa
PathwaysApoptosis, Autophagy, Glycolysis, Immune Response, Inflammasome
UniProt IDP06733
NCBI Gene ID2023
Ensembl IDENSG00000169064
OMIM172430
GeneCardsENO1
Human Protein AtlasENO1
N-terminal domain (aa 1-150)Involved in dimerization and protein-protein interactions with various binding partners
Associated DiseasesAging, Cancer, Carcinoma, Ms, Parkinson, Tumor
InteractionsAND, APOPTOSIS, ATP, CANCER, CD4, C-MYC
KG Connections155 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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Related Hypotheses (8)

Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73
Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
Nucleolar Stress Response Normalization
Score: 0.65
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62

Related Analyses (2)

Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

ATP P2X3 Receptor Neurons
cell · KG edge: inhibits
Apoptosis in Neurodegeneration
entity · KG edge: inhibits
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: regulates
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: activates
ATM Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

ENO1 participates_in glycolysis
PSMB9 associated_with ENO1
ENO1 associated_with DDX5
ENO1 associated_with CD8
ENO1 associated_with ATM
ENO1 biomarker_for DNAJA1
ENO1 interacts_with HSPA1A
ENO1 interacts_with FLT1
ENO1 interacts_with HSPA8
ENO1 biomarker_for GPX4

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