protein

TH PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TH PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3Connections

0Hypotheses

0Analyses

0Outgoing

3Incoming

0Experiments

0Debates

Summary

Tyrosine hydroxylase is the rate-limiting enzyme in catecholamine biosynthesis, converting L-tyrosine to L-DOPA in dopaminergic neurons; critical for Parkinson's disease and related disorders

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🔬 Protein Info

Gene Symbol	TH
Full Name	Tyrosine Hydroxylase
Chromosome	11p15.5
Protein Type	Enzyme
Target Class	Enzyme
Function	is an important component in the neurobiology of neurodegenerative diseases.
Mechanism of Action	Enzyme replacement therapy via L-DOPA supplementation to bypass reduced TH activity
Druggability	Medium (0.54)
Clinical Stage	Approved
Molecular Weight	58.5 kDa
Amino Acids	528 aa
UniProt ID	P07101
NCBI Gene ID	7067
Ensembl ID	ENSG00000180176
OMIM	191290
GeneCards	TH
Human Protein Atlas	TH
Associated Diseases	AUTOPHAGY, DOPAMINE, ER STRESS, FIBROSIS, FRONTOTEMPORAL DEMENTIA, INFLAMMATION
Known Drugs/Compounds	curcumin, dimethyl fumarate, L-DOPA, levodopa, LEVODOPA, rapamycin
Interactions	AADC, ACHE, AD, AIF, AKT, AMPK
SciDEX Target	View Target Profile (8 clinical trials)
KG Connections	742 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TH PROTEIN — AlphaFold P07101 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

graph TD
    TH_PROTEIN["TH PROTEIN"]
    ENDOG["ENDOG"]
    ENDOG -->|"co_discussed"| TH_PROTEIN
    PARKIN["PARKIN"]
    PARKIN -->|"co_discussed"| TH_PROTEIN
    PINK1["PINK1"]
    PINK1 -->|"co_discussed"| TH_PROTEIN
    style TH_PROTEIN fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (3)

Source	Relation	Type	Str
ENDOG	co_discussed	protein	0.50
PARKIN	co_discussed	gene	0.50
PINK1	co_discussed	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TH PROTEIN in their description or question text

No additional research found